Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers

IF 1.9 4区医学 Q3 PHYSIOLOGY Respiratory Physiology & Neurobiology Pub Date : 2024-02-01 DOI:10.1016/j.resp.2024.104228

Antonis Elia , Matthew J. Barlow , Matthew J. Lees , Georgios Petri , Michail E. Keramidas

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Abstract

Purpose

This study examined the magnitude of physiological strain imposed by repeated maximal static and dynamic apneas through assessing a panel of stress-related biomarkers.

Methods

Eleven healthy men performed on three separate occasions (≥72-h apart): a series of five repeated maximal (i) static (STA) or (ii) dynamic apneas (DYN) or (iii) a static eupneic protocol (CTL). Venous blood samples were drawn at 30, 90, and 180-min after each protocol to determine ischaemia modified albumin (IMA), neuron-specific enolase (NSE), myoglobin, and high sensitivity cardiac troponin T (hscTnT) concentrations.

Results

IMA was elevated after the apnoeic interventions (STA,+86%;DYN,+332%,p ≤ 0.047) but not CTL (p = 0.385). Myoglobin was higher than baseline (23.6 ± 3.9 ng/mL) 30-min post DYN (+70%,38.8 ± 13.3 ng/mL,p = 0.030). A greater myoglobin release was recorded in DYN compared with STA and CTL (p ≤ 0.035). No changes were observed in NSE (p = 0.207) or hscTnT (p = 0.274).

Conclusions

Five repeated maximal DYN led to a greater muscle injury compared with STA but neither elicited myocardial injury or neuronal-parenchymal damage.

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非潜水员在重复一系列静态和动态呼吸暂停后的压力生物标志物变化

本研究通过评估一系列与应激相关的生物标记物，研究了重复最大静态和动态呼吸暂停所造成的生理应变程度。方法七名健康男性在三个不同的场合（间隔≥72 小时）分别进行了：一系列五次重复最大 (i) 静态 (STA) 或 (ii) 动态呼吸暂停 (DYN) 或 (iii) 静态呼吸暂停方案 (CTL)。在每个方案后 30、90 和 180 分钟抽取静脉血样本，以测定缺血修饰白蛋白（IMA）、神经元特异性烯醇化酶（NSE）、肌红蛋白和高灵敏度心肌肌钙蛋白 T（hscTnT）的浓度。结果IMA 在呼吸暂停干预后升高（STA,+86%; DYN,+332%,p≤0.047 ），但 CTL 没有升高（p=0.385）。DYN 后 30 分钟，肌红蛋白高于基线（23.6±3.9 ng/mL）（+70%,38.8±13.3 ng/mL,p=0.030）。与 STA 和 CTL 相比，DYN 的肌红蛋白释放量更大（p≤0.035）。结论与 STA 相比，重复 5 次最大 DYN 会导致更大的肌肉损伤，但都不会引起心肌损伤或神经元-实质损伤。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.