{"title":"Mild and efficient synthesis of para-substituted 2-hydroxymethyl piperazine....","authors":"Zijian Liang, Liyuan Guo, Qian Li, Chunyan Liu, Chao Liu, Shi Wu","doi":"10.2174/0115701786283816240123103232","DOIUrl":null,"url":null,"abstract":"Herein, we present a mild and effective synthetic method for preparing para-substituted 2-hydroxymethyl piperazine from serine methyl ester and L-amino acids with residues of different sizes. This synthetic route has several advantages including mild reaction conditions, availability of reagents, non-racemic composition, and the potential for gram-scale synthesis. Notably, the compound (4g) demonstrated excellent yields in our experiments.","PeriodicalId":18116,"journal":{"name":"Letters in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Letters in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0115701786283816240123103232","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
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Abstract
Herein, we present a mild and effective synthetic method for preparing para-substituted 2-hydroxymethyl piperazine from serine methyl ester and L-amino acids with residues of different sizes. This synthetic route has several advantages including mild reaction conditions, availability of reagents, non-racemic composition, and the potential for gram-scale synthesis. Notably, the compound (4g) demonstrated excellent yields in our experiments.
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Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
The journal is an essential reading for all organic chemists belonging to both academia and industry.
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