Disruption of Resting-State Functional Connectivity in Acute Ischemic Stroke: Comparisons Between Right and Left Hemispheric Insults

IF 2.3 3区医学 Q3 CLINICAL NEUROLOGY Brain Topography Pub Date : 2024-02-01 DOI:10.1007/s10548-024-01033-7

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Abstract

Few resting-state functional magnetic resonance imaging (RS-fMRI) studies evaluated the impact of acute ischemic changes on cerebral functional connectivity (FC) and its relationship with functional outcomes after acute ischemic stroke (AIS), considering the side of lesions. To characterize alterations of FC of patients with AIS by analyzing 12 large-scale brain networks (NWs) with RS-fMRI. Additionally, we evaluated the impact of the side (right (RH) or left (LH) hemisphere) of insult on the disruption of brain NWs. 38 patients diagnosed with AIS (17 RH and 21 LH) who performed 3T MRI scans up to 72 h after stroke were compared to 44 healthy controls. Images were processed and analyzed with the software toolbox UF²C with SPM12. For the first level, we generated individual matrices based on the time series extraction from 70 regions of interest (ROIs) from 12 functional NWs, constructing Pearson’s cross-correlation; the second-level analysis included an analysis of covariance (ANCOVA) to investigate differences between groups. The statistical significance was determined with p < 0.05, after correction for multiple comparisons with false discovery rate (FDR) correction. Overall, individuals with LH insults developed poorer clinical outcomes after six months. A widespread pattern of lower FC was observed in the presence of LH insults, while a contralateral pattern of increased FC was identified in the group with RH insults. Our findings suggest that LH stroke causes a severe and widespread pattern of reduction of brain networks’ FC, presumably related to the impairment in their long-term recovery.

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急性缺血性脑卒中静息状态功能连通性的破坏：左右半球损伤的比较

摘要很少有静息态功能磁共振成像（RS-fMRI）研究评估急性缺血性改变对大脑功能连通性（FC）的影响及其与急性缺血性卒中（AIS）后功能预后的关系（考虑病变侧）。我们利用 RS-fMRI 分析了 12 个大规模脑网络（NW），以确定急性缺血性脑卒中患者的功能连通性变化特征。此外，我们还评估了损伤侧（右（RH）或左（LH）半球）对大脑网络破坏的影响。我们将中风后 72 小时内进行 3T MRI 扫描的 38 名确诊为 AIS 的患者（17 名右侧半球患者和 21 名左侧半球患者）与 44 名健康对照者进行了比较。我们使用带有 SPM12 的软件工具盒 UF2C 对图像进行了处理和分析。在第一级分析中，我们根据从 12 个功能性 NW 的 70 个感兴趣区（ROI）中提取的时间序列生成单个矩阵，构建皮尔逊交叉相关；第二级分析包括协方差分析（ANCOVA），以研究组间差异。经假发现率（FDR）校正进行多重比较后，以 p < 0.05 为统计学意义。总体而言，LH损伤患者在6个月后的临床结果较差。在 LH 受损的人群中，FC 普遍降低，而在 RH 受损的人群中，FC 反而升高。我们的研究结果表明，LH 中风会导致大脑网络 FC 严重而广泛的降低，这可能与其长期恢复能力受损有关。

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来源期刊

Brain Topography 医学-临床神经学

CiteScore

4.70

自引率

7.40%

发文量

审稿时长

3 months

期刊介绍： Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.