5-HT1F agonists.

Q2 Medicine Handbook of clinical neurology Pub Date : 2024-01-01 DOI:10.1016/B978-0-12-823357-3.00032-X

Stephanie J Steel

引用次数: 0

Abstract

5-Hydroxytryptamine (HT)/serotonin receptor agonism has been a long-recognized property of triptan medications, and more recently, the study and development of medications with selective binding to the 1F receptor subtype have been explored. While the exact mechanism contributing to decreased symptoms of an acute migraine attack remains unclear, selective 5-HT1F agonists have demonstrated clinical efficacy with lasmiditan as the only approved medication from this class to date. Lasmiditan lacks vasoconstrictive properties, giving it utility in specific patient populations in whom triptans should be avoided. Availability, central nervous system (CNS) side effects, and 8-hour driving restriction may affect its clinical use.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

5-HT1F 激动剂

5-羟色胺（HT）/羟色胺受体激动作用是三苯氧胺类药物长期以来公认的特性，最近，人们开始研究和开发可选择性结合1F受体亚型的药物。虽然导致偏头痛急性发作症状减轻的确切机制仍不清楚，但选择性5-HT1F激动剂已显示出临床疗效，迄今为止，拉斯米丹是该类药物中唯一获得批准的药物。拉斯米迪坦不具有血管收缩特性，因此可用于应避免使用曲坦类药物的特定患者群体。其供应、中枢神经系统（CNS）副作用和 8 小时驾驶限制可能会影响其临床使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.

期刊最新文献

5-HT1F agonists. Biobehavioral treatments of migraine. CGRP monoclonal antibodies and CGRP receptor antagonists (Gepants) in migraine prevention. CGRP receptor antagonists (gepants). Comorbidities of migraine: Sleep disorders.