Molecular Insights of Nonalcoholic Fatty Liver Disease Pathogenesis.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI:10.1089/jir.2023.0162
Reham Mohammed Dawood, Ghada Maher Salum, Mai Abd El-Meguid, Basma El-Sayed Fotouh
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Abstract

Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent chronic liver disease. Many hepatic abnormalities are associated with NAFLD such as nonalcoholic steatohepatitis, progressive fibrosis, cirrhosis, and liver failure. Moreover, the pathogenesis of NAFLD has numerous etiologies and can be explained due to the existence of several of stimulus that act simultaneously on genetically susceptible patients. These stimuli include obesity, diabetes, and insulin resistance. In addition, identifying the role of gut microbiota on NAFLD progression has been illustrated. In this review, we clarified the several factors that lead to the development of NAFLD and identify those who are most at risk of developing liver end-stage disease. Highlighting the noninvasive diagnostic NAFLD markers could be helpful in the disease prevention and treatment approaches.

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非酒精性脂肪肝发病机制的分子洞察。
非酒精性脂肪肝(NAFLD)是目前最普遍的慢性肝病。许多肝功能异常都与非酒精性脂肪肝有关,如非酒精性脂肪性肝炎、进行性纤维化、肝硬化和肝功能衰竭。此外,非酒精性脂肪肝的发病机制有多种病因,可以解释为存在多种刺激因素,同时作用于遗传易感患者。这些刺激因素包括肥胖、糖尿病和胰岛素抵抗。此外,肠道微生物群对非酒精性脂肪肝进展的作用也得到了证实。在这篇综述中,我们阐明了导致非酒精性脂肪肝发展的几个因素,并确定了哪些人最有可能发展成肝脏终末期疾病。强调非侵入性非酒精性脂肪肝诊断标志物有助于疾病的预防和治疗。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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