Extracellular matrix is the main targeted environment in early stage of pancreatic ductal adenocarcinoma.

Q3 Medicine Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI:10.22037/ghfbb.v16i4.2859

Vahid Mansouri, Babak Arjmand, Maryam Hamzeloo-Moghadam, Zahra Razzaghi, Alireza Ahmadzadeh, Mohammad Javad Ehsani Ardakani, Reza Mohamoud Robati

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Abstract

Aim: Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.

Background: PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.

Methods: Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology.

Results: Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13" group of 52 biological terms were identified as the main affected terms.

Conclusion: In conclusion, ALB, MMP1, and COL1A1 genes were highlighted as possible biomarkers of early stage of PDAC. Dysfunction of extracellular matrix was identified as a main event in patients.

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细胞外基质是胰腺导管腺癌早期的主要靶环境。

目的：由于胰腺导管腺癌（PDAC）的诊断和治疗能力较弱，本研究的主要目的是检测PDAC早期可能的生物标志物：背景：众所周知，PDAC是一种外分泌癌，其5年总生存率为11%：方法：从基因表达总库（GEO）下载早期PDAC组织和正常组织的基因表达谱，并通过GEO2R进行评估。方法：从基因表达总库（GEO）中下载早期PDAC组织和正常组织的基因表达谱，并通过GEO2R进行评估，通过蛋白-蛋白相互作用（PPI）网络分析和基因本体论研究重要的差异表达基因（DEGs）：结果：在104个DEGs中，ALB、COL1A1、COL1A2、MMP1、POSTN、PLAU和COL3A1被认为是中心节点。"MMP1、2、3、7、8、9、12、13的明胶降解 "等52个生物术语被确定为主要受影响术语：总之，ALB、MMP1 和 COL1A1 基因可能是 PDAC 早期的生物标志物。细胞外基质的功能障碍被认为是患者的主要疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology and Hepatology From Bed to Bench Medicine-Gastroenterology

CiteScore

2.30

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0.00%

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