Therapeutic potential of vasopressin in the treatment of neurological disorders

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptides Pub Date : 2024-02-01 DOI:10.1016/j.peptides.2024.171166

Shweta Mishra , Jyoti Grewal , Pranay Wal , Gauri U. Bhivshet , Arpan Kumar Tripathi , Vaibhav Walia

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Abstract

Vasopressin (VP) is a nonapeptide made of nine amino acids synthesized by the hypothalamus and released by the pituitary gland. VP acts as a neurohormone, neuropeptide and neuromodulator and plays an important role in the regulation of water balance, osmolarity, blood pressure, body temperature, stress response, emotional challenges, etc. Traditionally VP is known to regulate the osmolarity and tonicity. VP and its receptors are widely expressed in the various region of the brain including cortex, hippocampus, basal forebrain, amygdala, etc. VP has been shown to modulate the behavior, stress response, circadian rhythm, cerebral blood flow, learning and memory, etc. The potential role of VP in the regulation of these neurological functions have suggested the therapeutic importance of VP and its analogues in the management of neurological disorders. Further, different VP analogues have been developed across the world with different pharmacotherapeutic potential. In the present work authors highlighted the therapeutic potential of VP and its analogues in the treatment and management of various neurological disorders.

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血管加压素在治疗神经系统疾病方面的治疗潜力。

血管加压素（VP）是一种由九种氨基酸组成的非肽类物质，由下丘脑合成，由垂体释放。加压素是一种神经激素、神经肽和神经调节剂，在调节水平衡、渗透压、血压、体温、应激反应、情绪挑战等方面发挥着重要作用。传统上，VP 有调节渗透压和补液的作用。VP 及其受体广泛表达于大脑皮层、海马、基底前脑、杏仁核等不同区域。研究表明，VP 可调节行为、应激反应、昼夜节律、脑血流量、学习和记忆等。VP 在调节这些神经功能方面的潜在作用表明，VP 及其类似物在治疗神经系统疾病方面具有重要意义。此外，世界各地还开发出了不同的 VP 类似物，它们具有不同的药理治疗潜力。在本研究中，作者强调了 VP 及其类似物在治疗和控制各种神经系统疾病方面的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Peptides 医学-生化与分子生物学

CiteScore

6.40

自引率

6.70%

发文量

130

审稿时长

28 days

期刊介绍： Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.