Mechanisms of Stem Cells and Their Secreted Exosomes in the Treatment of Autoimmune Diseases.

Shu-Qian Lin, Kai Wang, Xing-Hua Pan, Guang-Ping Ruan
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Abstract

Stem cells play a therapeutic role in many diseases by virtue of their strong self-renewal and differentiation abilities, especially in the treatment of autoimmune diseases. At present, the mechanism of the stem cell treatment of autoimmune diseases mainly relies on their immune regulation ability, regulating the number and function of auxiliary cells, anti-inflammatory factors and proinflammatory factors in patients to reduce inflammation. On the other hand, the stem cell- derived secretory body has weak immunogenicity and low molecular weight, can target the site of injury, and can extend the length of its active time in the patient after combining it with the composite material. Therefore, the role of secretory bodies in the stem cell treatment of autoimmune diseases is increasingly important.

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干细胞及其分泌的外泌体治疗自身免疫性疾病的机制。
干细胞凭借其强大的自我更新和分化能力,在许多疾病中发挥着治疗作用,尤其是在自身免疫性疾病的治疗中。目前,干细胞治疗自身免疫性疾病的机理主要是依靠其免疫调节能力,调节患者体内辅助细胞、抗炎因子和促炎因子的数量和功能,达到消炎的目的。另一方面,干细胞衍生的分泌体免疫原性弱、分子量低,可靶向损伤部位,与复合材料结合后可延长其在患者体内的活性时间。因此,分泌体在干细胞治疗自身免疫性疾病中的作用越来越重要。
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