Triangular fuzzy number for similarity measurement of Y chromosome DNA profile

Meira Parma Dewi, A. Arymurthy, Suryana Setiawan, N. Soedarsono
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Abstract

This study measures the similarity of the short tandem repeat (STR) profile of human DNA. The similarity measurement had been done to the STR value of the allele loci in DNA profile between the query’s DNA to the reference’s DNA profile. The measurements were conducted on 27 DNA profile loci including the Y chromosome loci (YSTR). The YSTR loci were used as the main comparison of similarity measurements to determine the biological kinship relationship between the query DNA profile and the alleged male biological family. To measure the similarity of two STR values that have shifted due to several factors in the DNA source extraction process, a fuzzy similarity measure was used. The STR values of the DNA profile loci are described as triangular fuzzy numbers. Similarity value of the STR is the intersection of two isosecle that been compared. To conclude that the query has a biological relationship with the male reference, the similarity of the YSTR locus is equal or more than 0.75 and the similarity value of the other 24 DNA profile loci is greater or equal to 0.5. From the trial that have been done, 90% give the right results.
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用于测量 Y 染色体 DNA 图谱相似度的三角模糊数
这项研究测量的是人类 DNA 短串联重复序列(STR)图谱的相似性。相似性测量是针对查询 DNA 与参照 DNA DNA 图谱中等位基因位点的 STR 值进行的。测量针对 27 个 DNA 图谱位点,包括 Y 染色体位点(YSTR)。YSTR 位点被用作相似性测量的主要比较,以确定查询 DNA 图谱与所称男性生物家族之间的生物亲缘关系。在 DNA 源提取过程中,两个 STR 值因多种因素发生了偏移,为了测量这两个 STR 值的相似性,采用了模糊相似性测量法。DNA 图谱位点的 STR 值被描述为三角形模糊数。STR 的相似度值是比较过的两个等值线的交集。如果 YSTR 位点的相似度大于或等于 0.75,且其他 24 个 DNA 图谱位点的相似度大于或等于 0.5,则可以断定查询结果与男性参照物具有生物学关系。从已完成的试验来看,90% 的结果是正确的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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