The role of NLRP3 inflammasome in aging and age-related diseases

IF 5.2 2区医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2024-02-05 DOI:10.1186/s12979-023-00395-z

Ruikai Liang, Xinrui Qi, Qi Cai, Liyan Niu, Xi Huang, Deju Zhang, Jitao Ling, Yuting Wu, Yixuan Chen, Pingping Yang, Jianping Liu, Jing Zhang, Peng Yu

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Abstract

The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and mechanism related to aging like chronic low-grade inflammation. The NOD-like receptor protein 3 (NLRP3), a key regulator of the innate immune response, recognizes molecular patterns associated with pathogens and injury, initiating an intrinsic inflammatory immune response. Dysfunctional NLRP3 is linked to the onset of related diseases, particularly in the context of aging. Therefore, a profound comprehension of the regulatory mechanisms of the NLRP3 inflammasome in aging-related diseases holds the potential to enhance treatment strategies for these conditions. In this article, we review the significance of the NLRP3 inflammasome in the initiation and progression of diverse aging-related diseases. Furthermore, we explore preventive and therapeutic strategies for aging and related diseases by manipulating the NLRP3 inflammasome, along with its upstream and downstream mechanisms.

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NLRP3 炎症小体在衰老和老年相关疾病中的作用

全球人口逐渐老龄化，导致老年相关疾病激增，严重威胁人类健康。研究人员致力于了解和应对衰老的复杂性，不断揭示与衰老相关的物质和机制，如慢性低度炎症。NOD 样受体蛋白 3（NLRP3）是先天性免疫反应的关键调节因子，它能识别与病原体和损伤相关的分子模式，启动内在炎症免疫反应。功能失调的 NLRP3 与相关疾病的发病有关，尤其是在衰老的背景下。因此，深刻理解 NLRP3 炎性体在衰老相关疾病中的调控机制，有可能加强这些疾病的治疗策略。在本文中，我们回顾了 NLRP3 炎症小体在多种衰老相关疾病的发生和发展过程中的重要作用。此外，我们还探讨了通过操纵 NLRP3 炎性体及其上下游机制来预防和治疗衰老及相关疾病的策略。

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来源期刊

Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY

CiteScore

10.20

自引率

3.80%

发文量

期刊介绍： Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.