Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders.

IF 6.9 2区 生物学 Q1 CELL BIOLOGY Cold Spring Harbor perspectives in biology Pub Date : 2024-07-01 DOI:10.1101/cshperspect.a041356
Shane A Liddelow, Michelle L Olsen, Michael V Sofroniew
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Abstract

In addition to their many functions in the healthy central nervous system (CNS), astrocytes respond to CNS damage and disease through a process called "reactivity." Recent evidence reveals that astrocyte reactivity is a heterogeneous spectrum of potential changes that occur in a context-specific manner. These changes are determined by diverse signaling events and vary not only with the nature and severity of different CNS insults but also with location in the CNS, genetic predispositions, age, and potentially also with "molecular memory" of previous reactivity events. Astrocyte reactivity can be associated with both essential beneficial functions as well as with harmful effects. The available information is rapidly expanding and much has been learned about molecular diversity of astrocyte reactivity. Emerging functional associations point toward central roles for astrocyte reactivity in determining the outcome in CNS disorders.

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反应性星形胶质细胞和在中枢神经系统 (CNS) 疾病中的新作用。
星形胶质细胞除了在健康的中枢神经系统(CNS)中发挥多种功能外,还通过一种称为 "反应性 "的过程对中枢神经系统损伤和疾病做出反应。最近的证据显示,星形胶质细胞的反应性是一种以特定环境方式发生的潜在变化的异质性谱系。这些变化由不同的信号事件决定,不仅随不同中枢神经系统损伤的性质和严重程度而变化,而且随中枢神经系统的位置、遗传倾向、年龄而变化,还可能随先前反应事件的 "分子记忆 "而变化。星形胶质细胞的反应性既可能与基本的有益功能有关,也可能与有害影响有关。现有的信息正在迅速扩展,人们对星形胶质细胞反应性的分子多样性有了更多的了解。新出现的功能性关联表明,星形胶质细胞反应性在决定中枢神经系统疾病的结果方面发挥着核心作用。
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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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