Bioengineering vascularized liver tissue for biomedical research and application.

IF 1.6 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Scandinavian Journal of Gastroenterology Pub Date : 2024-05-01 Epub Date: 2024-02-06 DOI:10.1080/00365521.2024.2310172
Parsa Davoodi, Niloofar Rezaei, Moustapha Hassan, David C Hay, Massoud Vosough
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Abstract

The liver performs a wide range of biological functions that are essential to body homeostasis. Damage to liver tissue can result in reduced organ function, and if chronic in nature can lead to organ scarring and progressive disease. Currently, donor liver transplantation is the only longterm treatment for end-stage liver disease. However, orthotopic organ transplantation suffers from several drawbacks that include organ scarcity and lifelong immunosuppression. Therefore, new therapeutic strategies are required. One promising strategy is the engineering of implantable and vascularized liver tissue. This resource could also be used to build the next generation of liver tissue models to better understand human health, disease and aging in vitro. This article reviews recent progress in the field of liver tissue bioengineering, including microfluidic-based systems, bio-printed vascularized tissue, liver spheroids and organoid models, and the induction of angiogenesis in vivo.

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用于生物医学研究和应用的血管化肝脏组织生物工程。
肝脏具有多种生物功能,对人体平衡至关重要。肝脏组织受损会导致器官功能减退,如果长期如此,还会导致器官瘢痕形成和疾病进展。目前,供体肝移植是治疗终末期肝病的唯一长期疗法。然而,正位器官移植有几个缺点,包括器官稀缺和终身免疫抑制。因此,需要新的治疗策略。其中一个很有前景的策略是对可植入的血管化肝脏组织进行工程改造。这一资源还可用于建立下一代肝组织模型,以更好地了解人类健康、疾病和体外衰老。本文回顾了肝组织生物工程领域的最新进展,包括基于微流体的系统、生物打印血管化组织、肝球和类器官模型,以及体内血管生成的诱导。
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来源期刊
CiteScore
3.40
自引率
5.30%
发文量
222
审稿时长
3-8 weeks
期刊介绍: The Scandinavian Journal of Gastroenterology is one of the most important journals for international medical research in gastroenterology and hepatology with international contributors, Editorial Board, and distribution
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