Analyzing of L-tryptophan thermodynamics and its solubility in aqueous acetonitrile blends at diverse temperatures

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biophysical chemistry Pub Date : 2024-02-01 DOI:10.1016/j.bpc.2024.107195

Avishek Saha , Sourav Ghosh , Sintu Ganai , Puspal Mukherjee , Kalachand Mahali , Bidyut Saha , A.M.A. Henaish , Partha Sarathi Guin , Perwez Alam , Sanjay Roy

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Abstract

This paper delves into an investigation of the solubility characteristics of L-tryptophan within binary solvent systems containing aqueous acetonitrile. The primary emphasis of the study revolves around assessments based on mole fractions. The study utilizes these solubility values to assess thermodynamic constraints, including solution entropies and solution transfer free energetics. The calculated thermodynamic energies are correlated with interaction parameters, including Gibbs free energies and entropies, pertaining to the transfer of L-tryptophanfrom water to binary solvent blends of acetonitrile and water. Mathematical expressions are utilized to determine the transfer Gibbs free energies for chemical interactions, and the consequent entropies are clarified within the framework of solvent-solvent interactions. To expound upon the stability of L-tryptophan within the water-acetonitrile mixed system, we investigate the energetic aspects related to the transfer of chemicals Gibbs free energies. Additionally, standard temperature (298.15 K) is employed to calculate various related physicochemical parameters of solute/solvent.

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不同温度下 L-色氨酸热力学及其在水性乙腈混合物中的溶解度分析

本文深入研究了 L-色氨酸在含有乙腈水溶液的二元溶剂体系中的溶解特性。研究的主要重点是根据分子分数进行评估。研究利用这些溶解度值来评估热力学约束条件，包括溶液熵和溶液转移自由能。计算出的热力学能量与相互作用参数相关联，包括与 L-色氨酸从水转移到乙腈和水的二元溶剂混合物有关的吉布斯自由能和熵。利用数学表达式确定了化学作用的转移吉布斯自由能，并在溶剂-溶剂相互作用的框架内阐明了相应的熵。为了阐述 L-色氨酸在水-乙腈混合体系中的稳定性，我们研究了与化学物质转移吉布斯自由能相关的能量方面。此外，我们还采用标准温度（298.15 K）来计算溶质/溶剂的各种相关物理化学参数。

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来源期刊

Biophysical chemistry 生物-生化与分子生物学

CiteScore

6.10

自引率

10.50%

发文量

121

审稿时长

20 days

期刊介绍： Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.