Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens.

IF 1.7 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-02-07 DOI:10.1080/10495398.2024.2309955

Mustafa Bastamy, Ismail Raheel, Ahmed Elbestawy, Mohamed Diab, Enas Hammad, Lamiaa Elebeedy, Amal M El-Barbary, Ghadeer M Albadrani, Mohamed M Abdel-Daim, Mervat A Abdel-Latif, Ahmed Orabi

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Abstract

Lysozymes, efficient alternative supplements to antibiotics, have several benefits in poultry production. In the present study, 120, one-day-old, Ross 308 broiler chickens of mixed sex, were allocated into 2 equal groups, lysozyme treated group (LTG) and lysozyme free group (LFG), to evaluate the efficacy of lysozyme (Lysonir^®) usage via both drinking water (thrice) and spray (once). LTG had better (p = 0.042) FCR, and higher European production efficiency factor compared to LFG (p = 0.042). The intestinal integrity score of LTG was decreased (p = 0.242) compared to that of LFG; 0.2 vs. 0.7. Higher (p ≤ 0.001) intestinal Lactobacillus counts were detected in chickens of LTG. Decreased (p ≤ 0.001) IL-1β and CXCL8 values were reported in LTG. The cellular immune modulation showed higher (p ≤ 0.001) opsonic activity (MΦ and phagocytic index) in LTG vs. LFG at 25 and 35 days. Also, higher (p ≤ 0.001) local, IgA, and humoral, HI titers, for both Newcastle, and avian influenza H5 viruses were found in LTG compared to LFG. In conclusion, microbial lysozyme could improve feed efficiency, intestinal integrity, Lactobacillus counts, anti-inflammatory, and immune responses in broiler chickens.

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水溶液微生物溶菌酶对肉鸡的益生菌后作用、抗炎作用和免疫调节作用。

溶菌酶是抗生素的有效替代品，在家禽生产中具有多种益处。在本研究中，120 只一天龄的罗斯 308 混血肉鸡被平均分为两组，即溶菌酶处理组（LTG）和无溶菌酶组（LFG），以评估通过饮水（三次）和喷雾（一次）使用溶菌酶（Lysonir®）的效果。与LFG相比，LTG的FCR更好（p = 0.042），欧洲生产效率系数更高（p = 0.042）。与 LFG 相比，LTG 的肠道完整性评分降低（p = 0.242）；0.2 对 0.7。在长毛鸡的肠道中检测到更多的乳酸杆菌（p ≤ 0.001）。据报告，LTG 的 IL-1β 和 CXCL8 值降低（p ≤ 0.001）。细胞免疫调节显示，在 25 天和 35 天时，LTG 与 LFG 相比，opsonic 活性（MΦ 和吞噬指数）更高（p ≤ 0.001）。此外，与 LFG 相比，LTG 对新城疫和禽流感 H5 病毒的局部 IgA 和体液 HI 滴度更高（p ≤ 0.001）。总之，微生物溶菌酶可提高肉鸡的饲料效率、肠道完整性、乳酸杆菌数量、抗炎和免疫反应。

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来源期刊

Animal Biotechnology 工程技术-奶制品与动物科学

CiteScore

2.90

自引率

5.40%

发文量

230

审稿时长

>12 weeks

期刊介绍： Biotechnology can be defined as any technique that uses living organisms (or parts of organisms like cells, genes, proteins) to make or modify products, to improve plants, animals or microorganisms for a specific use. Animal Biotechnology publishes research on the identification and manipulation of genes and their products, stressing applications in domesticated animals. The journal publishes full-length articles and short research communications, as well as comprehensive reviews. The journal also provides a forum for regulatory or scientific issues related to cell and molecular biology applied to animal biotechnology. Submissions on the following topics are particularly welcome: - Applied microbiology, immunogenetics and antibiotic resistance - Genome engineering and animal models - Comparative genomics - Gene editing and CRISPRs - Reproductive biotechnologies - Synthetic biology and design of new genomes