Structure analysis of depsides, dibenzofuran and sugar derivatives from Cladia aggregata (SW) Nyl using ultra-performance liquid chromatography-tandem mass spectrometry.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 Epub Date: 2024-02-06 DOI:10.1177/14690667241229910

Priyanka Rawat, Sajan Lal Shyaula, Yatendra Singh, Sanjeev Kanojiya

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Abstract

Cladia aggregate (SW) Nyl is a lichenized fungi in the family Cladoniaceae producing characteristic secondary metabolites of interest. There are only limited chemical studies relating to the genus Cladia. A chemical study of the lichen C. aggregata was conducted and their chemical constituents were elucidated by ultra-performance liquid chromatography-electrospray ionization/triple-quadrupole tandem-mass spectrometry analysis. It is the first time report of structure analysis of its metabolite by liquid chromatography-mass spectrometry/mass spectrometry. The molecular masses for 20 compounds were detected from different fractions. Seven compounds were elucidated with mass spectrometry/mass spectrometry fragmentation pattern analysis. Barbatic acid (12) was identified as the major compound being common to all fractions. The identified compounds belong to depsides (2, 11, 12 and 20), dibenzofurans (13, 18) and sugar derivatives (1) which are usually distributed in lichens.

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利用超高效液相色谱-串联质谱法分析 Cladia aggregata (SW) Nyl 的去苷类化合物、二苯并呋喃类化合物和糖类衍生物的结构。

Cladia 聚合体（SW）Nyl 是一种地衣真菌，属于 Cladoniaceae 科，能产生特有的次级代谢物。目前，有关克拉地衣属的化学研究十分有限。本研究对地衣 C. aggregata 进行了化学研究，并通过超高效液相色谱-电喷雾离子化/三重四极杆串联质谱分析法阐明了其化学成分。这是首次报道利用液相色谱-质谱/质谱法对其代谢物进行结构分析。从不同的馏分中检测到了 20 种化合物的分子质量。通过质谱/质谱碎片模式分析，阐明了 7 种化合物。Barbatic 酸（12）被确定为所有馏分中常见的主要化合物。鉴定出的化合物属于通常分布在地衣中的去苷类化合物（2、11、12 和 20）、二苯并呋喃类化合物（13、18）和糖衍生物（1）。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.