Characteristics and outcomes of peripheral neuropathic pain patients with repeated applications of high-concentration capsaicin cutaneous patch: Results of a retrospective chart review in Germany.

IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pain Practice Pub Date : 2024-06-01 Epub Date: 2024-02-07 DOI:10.1111/papr.13345
Kai-Uwe Kern, Tamara Quandel, Sina Theis, Tino Schubert
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Abstract

Objective: The aim of this study was to evaluate patient characteristics, concomitant analgesic medication, and pain intensity in a real-world setting in Germany, focusing on the repeated application of high-concentration capsaicin patch (HCCP) for neuropathic pain.

Design: Data were collected from electronic medical records of patients who received at least two HCCP treatments between January 2011 and July 2022. Subgroup analyses were performed based on the number of HCCP treatments, age groups, and specific neuropathic pain conditions.

Setting: The study was conducted at an outpatient pain center in Wiesbaden, Germany.

Subjects: The study included 97 patients, primarily diagnosed with neuropathic back pain, postoperative or post-traumatic neuropathic pain, and postherpetic neuralgia.

Methods: The daily dose of concomitant medications (eg, opioids and anticonvulsants) at the start of capsaicin therapy was compared with the average within 2 years of capsaicin therapy. The last observation carried forward method was used if HCCP treatment was discontinued before the end of the 2-year period.

Results: The majority of patients received concomitant medications, with opioids, anticonvulsants, and antidepressants being the most common. The average daily morphine equivalent dose decreased significantly during HCCP treatment. Pain intensity at baseline was generally high, but substantial improvements were observed in patients who received at least three HCCP applications.

Conclusions: This study provides evidence for the effectiveness of HCCP treatment in reducing pain intensity and concomitant opioid use in patients with neuropathic pain. Further research is needed to explore the long-term outcomes and optimal treatment regimens for different patient populations.

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反复使用高浓度辣椒素皮肤贴片的周围神经痛患者的特征和疗效:德国回顾性病历审查结果。
研究目的本研究旨在评估德国真实世界中的患者特征、伴随镇痛药物和疼痛强度,重点关注重复应用高浓度辣椒素贴片(HCCP)治疗神经病理性疼痛:数据收集自 2011 年 1 月至 2022 年 7 月期间接受过至少两次 HCCP 治疗的患者的电子病历。根据HCCP治疗次数、年龄组和特定神经病理性疼痛情况进行分组分析:研究在德国威斯巴登的一家疼痛门诊中心进行:研究对象:97 名患者,主要诊断为神经病理性背痛、术后或创伤后神经病理性疼痛以及带状疱疹后遗神经痛:将开始接受辣椒素治疗时的每日伴随药物(如阿片类药物和抗惊厥药)剂量与接受辣椒素治疗两年内的平均剂量进行比较。如果在两年期结束前停止了辣椒素治疗,则采用最后观察结转法:结果:大多数患者都同时接受了药物治疗,其中阿片类药物、抗惊厥药和抗抑郁药最为常见。在HCCP治疗期间,每日吗啡当量的平均剂量明显减少。基线时的疼痛强度普遍较高,但在接受至少三次 HCCP 治疗的患者中观察到了明显的改善:这项研究为 HCCP 治疗在减轻神经病理性疼痛患者的疼痛强度和减少阿片类药物的同时使用方面的有效性提供了证据。需要进一步开展研究,探讨不同患者群体的长期疗效和最佳治疗方案。
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来源期刊
Pain Practice
Pain Practice ANESTHESIOLOGY-CLINICAL NEUROLOGY
CiteScore
5.60
自引率
3.80%
发文量
92
审稿时长
6-12 weeks
期刊介绍: Pain Practice, the official journal of the World Institute of Pain, publishes international multidisciplinary articles on pain and analgesia that provide its readership with up-to-date research, evaluation methods, and techniques for pain management. Special sections including the Consultant’s Corner, Images in Pain Practice, Case Studies from Mayo, Tutorials, and the Evidence-Based Medicine combine to give pain researchers, pain clinicians and pain fellows in training a systematic approach to continuing education in pain medicine. Prior to publication, all articles and reviews undergo peer review by at least two experts in the field.
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