Evaluating the Diagnostic Efficacy of 99mTc-Methionine Single-Photon Emission Computed Tomography-Computed Tomography: A Head-to-Head Comparison with 11C-Methionine Positron Emission Tomography-Magnetic Resonance Imaging in Glioma Patients.

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Cancer Biotherapy and Radiopharmaceuticals Pub Date : 2024-06-01 Epub Date: 2024-02-07 DOI:10.1089/cbr.2023.0147
Pardeep Kumar, Aishwarya Kumar, Chandana Nagaraj, Nishanth Sadashiva, Jitender Saini, Sandhya Mangalore, Archith Rajan, Keerti Sitani, Manish Beniwal, Vani Santosh, Harish Basavaraja, Puja Panwar Hazari, Anil Kumar Mishra
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Abstract

Background: Amino acid positron emission tomography (PET) imaging plays a significant role in the diagnosis of gliomas and in differentiating tumor recurrence from necrosis. In this study, the authors evaluated the diagnostic efficacy of [99mTc]Tc-methionine single-photon emission computed tomography-computed tomography (SPECT-CT) in comparison with [11C]methionine PET-magnetic resonance imaging (MRI) in delineating tumors. Methods: Thirty-one (primary: 16 and postoperative: 15) patients of confirmed (either MRI or histopathological proven) glioma underwent both [99mTc]Tc-methionine SPECT-CT and [11C]methionine PET-MRI. A comparative analysis was performed between SPECT, PET, and MR images to calculate the concordance between the modalities and to evaluate the diagnostic efficacy of the [99mTc]Tc-methionine SPECT. Results: [99mTc]Tc-methionine SPECT showed comparable uptake in the tumor lesions in comparison to [11C]methionine PET. A significant and strong positive correlation was observed between the volume of tumor (Vt) in PET and Vt MR (p < 0.004). Likewise, a significant and strong positive correlation was found between Vt SPECT and Vt MR. [99mTc]-methionine has a sensitivity and specificity of 91% and 75%, respectively, compared with 82% and 100% for [11C]methionine in postoperative cases to differentiate the tumor recurrence from necrosis. The sensitivity and specificity of [99mTc]Tc-methionine was 92% and 100%, respectively, compared with 92% and 67% for [11C]methionine in primary tumors. Conclusion: [99mTc]Tc-methionine SPECT-CT is as equally good as [11C]methionine for diagnosing and differentiating it from necrosis especially in high-grade glioma.

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评估99m锝-蛋氨酸单光子发射计算机断层扫描-计算机断层成像的诊断效果:在胶质瘤患者中与11C-蛋氨酸正电子发射计算机断层扫描-磁共振成像的头对头比较。
背景:氨基酸正电子发射计算机断层扫描(PET)成像在诊断胶质瘤和区分肿瘤复发与坏死方面发挥着重要作用。在这项研究中,作者评估了[99m锝]锝-蛋氨酸单光子发射计算机断层扫描(SPECT-CT)与[11C]蛋氨酸正电子发射计算机断层扫描-磁共振成像(MRI)在划定肿瘤界限方面的诊断效果。研究方法31名确诊(核磁共振成像或组织病理学证实)胶质瘤患者(原发性:16名,术后:15名)同时接受了[99m锝]锝蛋氨酸SPECT-CT和[11C]蛋氨酸PET-MRI检查。对 SPECT、PET 和 MR 图像进行了对比分析,以计算各种模式之间的一致性,并评估[99m锝]锝蛋氨酸 SPECT 的诊断效果。结果与[11C]蛋氨酸 PET 相比,[99m锝]锝蛋氨酸 SPECT 在肿瘤病灶中的摄取量相当。在术后病例中,[99m锝]蛋氨酸在区分肿瘤复发和坏死方面的敏感性和特异性分别为91%和75%,而[11C]蛋氨酸则分别为82%和100%。在原发性肿瘤中,[99mTc]锝-蛋氨酸的敏感性和特异性分别为 92% 和 100%,而[11C]蛋氨酸的敏感性和特异性分别为 92% 和 67%。结论[99m锝]锝-蛋氨酸SPECT-CT与[11C]蛋氨酸在诊断和鉴别肿瘤坏死(尤其是高级别胶质瘤)方面的效果相同。
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来源期刊
CiteScore
7.80
自引率
2.90%
发文量
87
审稿时长
3 months
期刊介绍: Cancer Biotherapy and Radiopharmaceuticals is the established peer-reviewed journal, with over 25 years of cutting-edge content on innovative therapeutic investigations to ultimately improve cancer management. It is the only journal with the specific focus of cancer biotherapy and is inclusive of monoclonal antibodies, cytokine therapy, cancer gene therapy, cell-based therapies, and other forms of immunotherapies. The Journal includes extensive reporting on advancements in radioimmunotherapy, and the use of radiopharmaceuticals and radiolabeled peptides for the development of new cancer treatments.
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