{"title":"Regional vulnerability to Aβ and tau pathology","authors":"Lisa Kiani","doi":"10.1038/s41582-024-00934-2","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2000,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neurology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41582-024-00934-2","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
最新研究发现，特定脑区对阿尔茨海默病（AD）病理学的脆弱性与AD易感基因的表达谱有关。为了描述区域脆弱性的特征，Yu 等人比较了认知障碍患者（包括阿兹海默症和轻度认知障碍）和认知功能未受损者的 tau 和淀粉样蛋白-β (Aβ) PET 成像数据。转录组分析揭示了45个AD易感基因的基因表达谱与区域对tau或Aβ沉积的易感性之间的空间关联。APOE和MAPT是与tau病理学关系最密切的基因，而TMEM106B（编码一种溶酶体膜蛋白）和CNTNAP2（参与神经胶质细胞的相互作用）则与Aβ病理学关系最密切。
期刊介绍：
Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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