Upcycling HOXB13: enhancing prostate cancer detection with a novel antibody†

IF 5.6 2区医学 Q1 ONCOLOGY The Journal of Pathology Pub Date : 2024-02-09 DOI:10.1002/path.6258

Anke Augspach, Mark A Rubin

引用次数: 0

Abstract

Prostate cancer is one of the most prevalent and, upon metastasis, deadliest cancers in men. Timely identification is essential for effective treatment. Furthermore, accurate determination of prostatic origin is crucial for personalized therapy once the cancer has spread. However, current prostate cancer screening methods are lacking. A recent article in The Journal of Pathology addresses this issue by utilizing an improved antibody to reevaluate HOXB13 as a lineage marker for prostate cancer. The study's findings support the concept that, despite decreased expression in advanced prostate cancer, HOXB13 remains highly suitable for determining prostatic origin due to its androgen receptor independence, high specificity, and sensitivity. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

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HOXB13上循环：利用新型抗体增强前列腺癌检测能力†。

前列腺癌是最常见的男性癌症之一，一旦发生转移，也是最致命的癌症。及时发现对有效治疗至关重要。此外，一旦癌症扩散，准确确定前列腺来源对于个性化治疗也至关重要。然而，目前还缺乏前列腺癌筛查方法。病理学杂志》（The Journal of Pathology）最近发表的一篇文章利用一种改良抗体重新评估了作为前列腺癌系标志物的 HOXB13，从而解决了这一问题。研究结果支持这样一种观点，即尽管HOXB13在晚期前列腺癌中的表达量有所下降，但由于其与雄激素受体无关、特异性强且灵敏度高，因此仍非常适合用于确定前列腺来源。© 2024 作者。病理学杂志》由 John Wiley & Sons Ltd 代表大不列颠及爱尔兰病理学会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Journal of Pathology 医学-病理学

CiteScore

14.10

自引率

1.40%

发文量

144

审稿时长

3-8 weeks

期刊介绍： The Journal of Pathology aims to serve as a translational bridge between basic biomedical science and clinical medicine with particular emphasis on, but not restricted to, tissue based studies. The main interests of the Journal lie in publishing studies that further our understanding the pathophysiological and pathogenetic mechanisms of human disease. The Journal of Pathology welcomes investigative studies on human tissues, in vitro and in vivo experimental studies, and investigations based on animal models with a clear relevance to human disease, including transgenic systems. As well as original research papers, the Journal seeks to provide rapid publication in a variety of other formats, including editorials, review articles, commentaries and perspectives and other features, both contributed and solicited.