Effect of Carob and Ginseng Supplements on Semen Analysis Parameters, Sexual Function, and Sex Hormones in Infertile Men: Double-Blind, Randomized Controlled Trial Study.

Abstract

Background: Infertility is one of the most common problems in the world; there is a growing demand for herbal medicines to treat infertility-related problems.

Materials and methods: A randomized controlled trial with three groups was conducted, each with 30 participants. The first group was administered 1.5 grams of Carob daily, the second group was administered 1.5 grams of Ginseng daily, and the third group received a placebo. The treatment was administered for 12 weeks, and before and after the intervention, semen parameters, testosterone, prolactin, luteinizing hormone, follicle-stimulating hormone, thyroid hormones, and sexual function were evaluated. Sexual function was assessed using the International Index of Erectile Function Questionnaire.

Results: The mean (SD) age of participants was 34.83 (6.22), 34.60 (5.78), and 33.67 (5.82) years in Carob, Ginseng, and Placebo groups, respectively. The results showed that in the Carob group, the normal volume of semen (Z ₁₃₃ = 3.05, p = 0.02) and the normal shape of sperm (Z ₁₃₄ = 2.97, p = 0.01) increased significantly compared to the control group. In the Ginseng group, the normal volume (Z ₁₃₃ = 3.90, p = 0.001) and the normal viscosity of semen (Z ₁₃₃ = 2.36, p = 0.01) increased significantly compared to the control group.The Carob group showed a significant increase in normal sperm counts and testosterone hormone levels (Z ₁₃₁ = 2.81, p = 0.05). The Ginseng group demonstrated a significant improvement in orgasm function (H₂ = 6.14, p = 0.04) and the total score of the International Index of Erectile Function (IIEF) (H₂ = 5.8, p = 0.05).

Conclusions: Carob supplements are suggested to enhance some semen parameters and male sex hormones. For infertile men, Ginseng can be beneficial in improving sexual function.