A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection

IF 7.9 2区 医学 Q1 IMMUNOLOGY Mucosal Immunology Pub Date : 2024-04-01 DOI:10.1016/j.mucimm.2024.02.003
Lucas M. Ethgen , Christopher Pastore , Cailu Lin , Danielle R Reed , Li-Yin Hung , Bonnie Douglas , Dominic Sinker , De'Broski R. Herbert , Nicole M. Belle
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Abstract

Host defense at the mucosal interface requires collaborative interactions between diverse cell lineages. Epithelial cells damaged by microbial invaders release reparative proteins such as the Trefoil factor family (TFF) peptides that functionally restore barrier integrity. However, whether TFF peptides and their receptors also serve instructive roles for immune cell function during infection is incompletely understood. Here, we demonstrate that the intestinal trefoil factor, TFF3, restrains (T cell helper) TH1 cell proliferation and promotes host-protective type 2 immunity against the gastrointestinal parasitic nematode Trichuris muris. Accordingly, T cell-specific deletion of the TFF3 receptor, leucine-rich repeat and immunoglobulin containing nogo receptor 2 (LINGO2), impairs TH2 cell commitment, allows proliferative expansion of interferon (IFN)g+ cluster of differentiation (CD)4+ TH1 cells and blocks normal worm expulsion through an IFNg-dependent mechanism. This study indicates that TFF3, in addition to its known tissue reparative functions, drives anti-helminth immunity by controlling the balance between TH1/TH2 subsets.

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在消化道线虫感染过程中,三叶草因子 3-Lingo2 轴抑制了 1 型 T 辅助细胞的增殖扩张。
黏膜界面的宿主防御需要不同细胞系之间的协作互动。被微生物入侵者破坏的上皮细胞会释放修复蛋白,如三叶草因子家族(TFF)肽,从而在功能上恢复屏障的完整性。然而,人们对 TFF 肽及其受体是否还能在感染期间对免疫细胞的功能起到指导作用尚不完全清楚。在这里,我们证明了肠道三叶草因子 TFF3 能抑制 TH1 细胞增殖并促进宿主保护性 2 型免疫,以对抗肠道寄生线虫毛滴虫。因此,T细胞特异性缺失TFF3受体Lingo2会损害TH2细胞的承诺,允许IFNγ+CD4+ TH1细胞增殖扩张,并通过IFNγ依赖性机制阻止正常的蠕虫驱逐。这项研究表明,TFF3除了具有已知的组织修复功能外,还能通过控制TH1/TH2亚群之间的平衡来驱动抗蠕虫免疫。
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来源期刊
Mucosal Immunology
Mucosal Immunology 医学-免疫学
CiteScore
16.60
自引率
3.80%
发文量
100
审稿时长
12 days
期刊介绍: Mucosal Immunology, the official publication of the Society of Mucosal Immunology (SMI), serves as a forum for both basic and clinical scientists to discuss immunity and inflammation involving mucosal tissues. It covers gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through original research articles, scholarly reviews, commentaries, editorials, and letters. The journal gives equal consideration to basic, translational, and clinical studies and also serves as a primary communication channel for the SMI governing board and its members, featuring society news, meeting announcements, policy discussions, and job/training opportunities advertisements.
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