The perfect storm: Cutaneous leishmaniasis in troops deployed in the Atlantic forest of Argentina

IF 2.4 2区农林科学 Q3 INFECTIOUS DISEASES Zoonoses and Public Health Pub Date : 2024-02-09 DOI:10.1111/zph.13115

Daniela Lamattina, Esteban Manuel Couto, Sofía Lorian Moya, Magalí Gabriela Giuliani, Micaela Cortés, María Victoria Vadell, Oscar Daniel Salomón

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Abstract

American cutaneous leishmaniasis (ACL) is the most prevalent form of leishmaniasis, associated with an ulcerative and stigmatizing mucocutaneous pathology. This study assessed the incidence of Leishmania (Viannia) braziliensis in members of the Argentine Army who were exposed to sandfly bites in Iguazú National Park (INP), northeastern Argentina, during an outbreak of ACL in 2019, and the presence of Leishmania in rodents, opossums and phlebotomine sandflies collected in the area of exposure. Samples from military personnel, wild animals and phlebotomine sandflies were analysed. A total of 20 (40%) patients among the Army personnel and two Akodon montensis rodents (11%) were positive for the presence of Leishmania sp. genes by PCR, while Nyssomyia whitmani and Migonemyia migonei, competent vectors of Leishmania, were also found at the same site. Sequences of hsp70 DNA fragments obtained from human samples confirmed the identity of L. (V.) braziliensis. The risk to which military personnel carrying out activities in the forest are exposed is highlighted, and this risk extends to any worker and visitor who circulates without protection in the INP, coming into contact with transmission “hot spots” due to the concentration of vectors, reservoirs and/or parasites.

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完美风暴：部署在阿根廷大西洋森林部队中的皮肤利什曼病。

美洲皮肤利什曼病（ACL）是利什曼病中最常见的一种，伴有溃疡和皮肤粘膜病变，令人鄙视。本研究评估了 2019 年爆发美洲利什曼病期间，在阿根廷东北部伊瓜苏国家公园（INP）被沙蝇叮咬的阿根廷军队成员中巴西利什曼病（Viannia）的发病率，以及在接触地区采集的啮齿动物、负鼠和噬血沙蝇中利什曼病的存在情况。对军事人员、野生动物和血吸沙蝇的样本进行了分析。通过聚合酶链式反应（PCR），军队人员中共有 20 名患者（40%）和两只 Akodon montensis 啮齿动物（11%）的利什曼原虫基因呈阳性，同时在同一地点还发现了利什曼原虫的有效载体 Nyssomyia whitmani 和 Migonemyia migonei。从人体样本中获得的 hsp70 DNA 片段的序列证实了巴西利什曼原虫的身份。在森林中开展活动的军事人员所面临的风险得到了强调，这种风险延伸到了在没有保护措施的情况下在国家公园内活动的任何工作人员和游客，他们会因病媒、水库和/或寄生虫的集中而接触到传播 "热点"。

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来源期刊

Zoonoses and Public Health 医学-传染病学

CiteScore

5.30

自引率

4.20%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.