Modulation of extrinsic apoptotic pathway by intracellular glycosylation.

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-09-01 Epub Date: 2024-02-08 DOI:10.1016/j.tcb.2024.01.003
Kamil Seyrek, Nikita V Ivanisenko, Corinna König, Inna N Lavrik
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Abstract

The importance of post-translational modifications (PTMs), particularly O-GlcNAcylation, of cytoplasmic proteins in apoptosis has been neglected for quite a while. Modification of cytoplasmic proteins by a single N-acetylglucosamine sugar is a dynamic and reversible PTM exhibiting properties more like phosphorylation than classical O- and N-linked glycosylation. Due to the sparse information existing, we have only limited understanding of how GlcNAcylation affects cell death. Deciphering the role of GlcNAcylation in cell fate may provide further understanding of cell fate decisions. This review focus on the modulation of extrinsic apoptotic pathway via GlcNAcylation carried out by O-GlcNAc transferase (OGT) or by other bacterial effector proteins.

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细胞内糖基化对细胞外凋亡途径的调节。
细胞质蛋白质的翻译后修饰(PTMs),特别是O-GlcNAcylation,在细胞凋亡中的重要性一直被忽视。单个 N-乙酰葡糖胺糖对细胞质蛋白质的修饰是一种动态、可逆的 PTM,与经典的 O- 和 N-连接糖基化相比,其性质更类似于磷酸化。由于现有信息稀少,我们对 GlcNAcylation 如何影响细胞死亡的了解十分有限。破译 GlcNAcylation 在细胞命运中的作用可能有助于进一步了解细胞命运的决定。这篇综述主要探讨了 O-GlcNAc转移酶(OGT)或其他细菌效应蛋白通过 GlcNAcylation 对细胞凋亡外途径的调节作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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