Signaling networks guiding erythropoiesis.

IF 3.1 3区医学 Q2 HEMATOLOGY Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-07 DOI:10.1097/MOH.0000000000000808

Shilpa Kuttikrishnan, Kirti S Prabhu, Abdul Q Khan, Shahab Uddin

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Abstract

Purpose of review: Cytokine-mediated signaling pathways, including JAK/STAT, PI3K/AKT, and Ras/MAPK pathways, play an important role in the process of erythropoiesis. These pathways are involved in the survival, proliferation, and differentiation function of erythropoiesis.

Recent findings: The JAK/STAT pathway controls erythroid progenitor differentiation, proliferation, and survival. The PI3K/AKT signaling cascade facilitates erythroid progenitor survival, proliferation, and final differentiation. During erythroid maturation, MAPK, triggered by EPO, suppresses myeloid genes, while PI3K is essential for differentiation. Pro-inflammatory cytokines activate signaling pathways that can alter erythropoiesis like EPOR-triggered signaling, including survival, differentiation, and proliferation.

Summary: A comprehensive understanding of signaling networks is crucial for the formulation of treatment approaches for hematologic disorders. Further investigation is required to fully understand the mechanisms and interactions of these signaling pathways in erythropoiesis.

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引导红细胞生成的信号网络。

综述目的：细胞因子介导的信号通路（包括 JAK/STAT、PI3K/AKT 和 Ras/MAPK 通路）在红细胞生成过程中发挥着重要作用。这些通路参与了红细胞的存活、增殖和分化功能：JAK/STAT 通路控制着红细胞祖细胞的分化、增殖和存活。PI3K/AKT 信号级联促进红细胞祖细胞的存活、增殖和最终分化。在红细胞成熟过程中，由 EPO 触发的 MAPK 会抑制髓系基因，而 PI3K 则对分化至关重要。促炎细胞因子激活的信号通路可改变红细胞生成，如 EPOR 触发的信号通路，包括存活、分化和增殖。要全面了解这些信号通路在红细胞生成过程中的机制和相互作用，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Hematology 医学-血液学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.