Multifunctional nanocoatings with synergistic controlled release of zinc ions and cytokines for precise modulation of vascular intimal reconstruction

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-02-08 DOI:10.1016/j.nano.2024.102739
Jianying Tan PhD , Huanran Wang Master's degree in engineering , Sainan Liu Master's degree in engineering , Li Li PhD , Hengquan Liu PhD , Tao Liu PhD , Junying Chen PhD
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Abstract

Vascular stent implantation remains the major therapeutic method for cardiovascular diseases currently. We here introduced crucial biological functional biological function factors (SDF-1α, VEGF) and vital metal ions (Zn2+) into the stent surface to explore their synergistic effect in the microenvironment. The combination of the different factors is known to effectively regulate cellular inflammatory response and selectively regulate cell biological behavior. Meanwhile, in the implemented method, VEGF and Zn2+ were loaded into heparin and poly-l-lysine (Hep-PLL) nanoparticles, ensuring a controlled release of functional molecules with a multi-factor synergistic effect and excellent biological functions in vitro and in vivo. Notably, after 150 days of implantation of the modified stent in rabbits, a thin and smooth new intima was obtained. This study offers a new idea for constructing a modified surface microenvironment and promoting tissue repair.

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协同控制锌离子和细胞因子释放的多功能纳米涂层,用于精确调节血管内膜重建。
血管支架植入术仍是目前治疗心血管疾病的主要方法。我们在此将重要的生物功能因子(SDF-1α、VEGF)和重要的金属离子(Zn2+)引入支架表面,探索它们在微环境中的协同作用。众所周知,不同因子的组合能有效调节细胞炎症反应,并选择性地调节细胞生物学行为。同时,在实施的方法中,VEGF 和 Zn2+ 被载入肝素和聚赖氨酸(Hep-PLL)纳米颗粒中,确保了功能分子的可控释放,具有多因素协同效应和优异的体内外生物功能。值得注意的是,改良支架在兔子体内植入 150 天后,可获得薄而光滑的新内膜。这项研究为构建改良表面微环境和促进组织修复提供了新思路。
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来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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