Quality of life, mood disorders, and cognitive impairment in adults with β-thalassemia

IF 6.9 2区 医学 Q1 HEMATOLOGY Blood Reviews Pub Date : 2024-02-08 DOI:10.1016/j.blre.2024.101181
Maya Bizri , Rawan Koleilat , Nathalie Akiki , Reem Dergham , Alexandra Monica Mihailescu , Rayan Bou-Fakhredin , Khaled M. Musallam , Ali T. Taher
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Abstract

Advances in understanding the disease process in β-thalassemia supported development of various treatment strategies that resulted in improved survival. Improved survival, however, allowed multiple morbidities to manifest and cemented the need for frequent, lifelong treatment. This has directly impacted patients' health-related quality of life and opened the door for various psychiatric and cognitive disorders to potentially develop. In this review, we summarize available evidence on quality of life, depression and anxiety, suicidality, and cognitive impairment in adult patients with β-thalassemia while sharing our personal insights from experience in treating patients with both transfusion-dependent and non-transfusion-dependent forms.

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β地中海贫血症成人患者的生活质量、情绪障碍和认知障碍。
随着人们对 β 地中海贫血症发病过程认识的不断深入,各种治疗策略应运而生,从而提高了患者的存活率。然而,存活率的提高使得多种疾病显现出来,并巩固了对频繁、终身治疗的需求。这直接影响了患者与健康相关的生活质量,并为各种精神和认知障碍的潜在发展打开了大门。在这篇综述中,我们总结了有关成年 β 地中海贫血症患者的生活质量、抑郁和焦虑、自杀和认知障碍的现有证据,同时分享了我们在治疗输血依赖型和非输血依赖型患者过程中的个人见解。
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来源期刊
Blood Reviews
Blood Reviews 医学-血液学
CiteScore
13.80
自引率
1.40%
发文量
78
期刊介绍: Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.
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