Prevalence, Risk Factors, and Prognostic Value of Anxiety and Depression in Acute Myeloid Leukemia.

IF 1.7 4区医学 Q3 HEMATOLOGY Acta Haematologica Pub Date : 2024-01-01 Epub Date: 2024-02-16 DOI:10.1159/000536457

Tao Zhong, Dan Xu, Wenchao Li

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Abstract

Introduction: Limited studies report anxiety and depression prevalence and their correlations with prognosis in acute myeloid leukemia (AML). Even worse, their risk factors for AML remained unclear. This study aimed to investigate the prevalence, risk factors, and prognostic value of anxiety and depression in AML patients.

Methods: Totally, 132 de novo AML patients, 60 non-malignant hematological disease patients (as disease controls), and 60 healthy controls were enrolled. Anxiety and depression status were evaluated by the Hospital Anxiety and Depression Scale (HADS) in all participants.

Results: HADS-anxiety score (8.2 ± 3.2 vs. 6.1 ± 2.9 vs. 4.7 ± 2.8), anxiety rate (48.5% vs. 25.0% vs. 10.0%), HADS-depression score (7.8 ± 3.0 vs. 5.8 ± 3.0 vs. 4.0 ± 2.8), and depression rate (43.2% vs. 23.3% vs. 8.3%) were highest in AML patients, followed by disease controls, and the lowest in healthy controls (all p < 0.001). Multivariate logistic regression analysis identified that factors independently associated with anxiety included male (p = 0.002, odds ratio [OR] = 0.240), smoking (p = 0.043, OR = 2.474), education duration (p = 0.024, OR = 0.889), and NCCN high-risk stratification (p = 0.008, OR = 2.347), while those independently associated with depression were age (p = 0.005, OR = 1.055), single/divorced/widowed status (p = 0.014, OR = 3.149), NCCN high-risk stratification (p = 0.002, OR = 3.077), and white blood cell (WBC) (p < 0.001, OR = 1.062). Additionally, depression was correlated with shorter accumulating event-free survival (p = 0.012) and overall survival (p = 0.041) in AML patients, whereas anxiety was not.

Conclusions: Anxiety and depression are prevalent, among which depression is associated with poor survival profile, but anxiety is not; moreover, age, male, education, single/divorced/widowed status, smoking, NCCN high-risk stratification, and WBC were independent related factors of anxiety and depression in AML patients.

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急性髓性白血病患者焦虑和抑郁的患病率、风险因素和预后价值。

导言：有关急性髓性白血病（AML）中焦虑和抑郁的发病率及其与预后的相关性的研究报告十分有限。更糟糕的是，它们在急性髓性白血病中的风险因素仍不明确。本研究旨在探讨焦虑和抑郁在急性髓性白血病患者中的患病率、风险因素和预后价值：方法：共纳入 132 名新发急性髓细胞性白血病患者、60 名非恶性血液病患者（作为疾病对照）和 60 名健康对照。所有参与者的焦虑和抑郁状况均通过医院焦虑抑郁量表（HADS）进行评估：结果：急性髓细胞性白血病患者的 HADS 焦虑评分（8.2±3.2 vs. 6.1±2.9 vs. 4.7±2.8）、焦虑率（48.5% vs. 25.0% vs. 10.0%）、HADS 抑郁评分（7.8±3.0 vs. 5.8±3.0 vs. 4.0±2.8）和抑郁率（43.2% vs. 23.3% vs. 8.3%）最高，疾病对照组次之，健康对照组最低（全部为 PConclusions：此外，年龄、男性、教育程度、单身/离异/丧偶状态、吸烟、NCCN高危分层和白细胞计数是急性髓细胞白血病患者焦虑和抑郁的独立相关因素。

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来源期刊

Acta Haematologica 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.