Tim Halstenbach, Annika Topitsch, Oliver Schilling, Gerhard Iglhaut, Katja Nelson, Tobias Fretwurst
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引用次数: 0
Abstract
Dental implants have been established as successful treatment options for missing teeth with steadily increasing demands. Today, the primary areas of research in dental implantology revolve around osseointegration, soft and hard tissue grafting as well as peri-implantitis diagnostics, prevention, and treatment. This review provides a comprehensive overview of the current literature on the application of MS-based proteomics in dental implant research, highlights how explorative proteomics provided insights into the biology of peri-implant soft and hard tissues and how proteomics facilitated the stratification between healthy and diseased implants, enabling the identification of potential new diagnostic markers. Additionally, this review illuminates technical aspects, and provides recommendations for future study designs based on the current evidence.
种植牙已成为治疗缺失牙的成功方法，其需求量也在稳步增长。如今，牙科种植学的主要研究领域围绕着骨结合、软组织和硬组织移植以及种植体周围炎的诊断、预防和治疗。这篇综述全面概述了基于 MS 的蛋白质组学在牙科种植研究中的应用，重点介绍了探索性蛋白质组学如何深入了解种植体周围软组织和硬组织的生物学特性，以及蛋白质组学如何促进健康种植体和病变种植体之间的分层，从而确定潜在的新诊断标记。此外，这篇综述还阐明了技术方面的问题，并根据现有证据为未来的研究设计提供了建议。
期刊介绍：
PROTEOMICS - Clinical Applications has developed into a key source of information in the field of applying proteomics to the study of human disease and translation to the clinic. With 12 issues per year, the journal will publish papers in all relevant areas including:
-basic proteomic research designed to further understand the molecular mechanisms underlying dysfunction in human disease
-the results of proteomic studies dedicated to the discovery and validation of diagnostic and prognostic disease biomarkers
-the use of proteomics for the discovery of novel drug targets
-the application of proteomics in the drug development pipeline
-the use of proteomics as a component of clinical trials.
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