T1 Mapping and Amide Proton Transfer Weighted Imaging for Predicting Lymph Node Metastasis in Patients with Rectal Cancer.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Current Medical Imaging Reviews Pub Date : 2024-02-09 DOI:10.2174/0115734056251952231012155314

Yue Wang, Anliang Chen, Wenjun Hu, Yuhui Liu, Jiazheng Wang, Liangjie Lin, Qingwei Song, Ailian Liu

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Abstract

Background: Accurate preoperative judgment of lymph node (LN) metastasis is a critical step in creating a treatment strategy and evaluating prognosis in rectal cancer (RC) patients.

Objective: This study aimed to explore the value of T1 mapping and amide proton transfer weighted (APTw) imaging in predicting LN metastasis in patients with rectal cancer.

Methods: In a retrospective study, twenty-three patients with pathologically confirmed rectal adenocarcinoma who underwent MRI and surgery from August 2019 to August 2021 were selected. Then, 3.0T/MR sequences included conventional sequences (T1WI, T2WI, and DWI), APTw imaging, and T1 mapping. Patients were divided into LN metastasis (group A) and non-LN metastasis groups (group B). The intra-group correlation coefficient (ICC) was used to test the inter-observer consistency. Mann-Whitney U test was used to compare the differences between the two groups. Spearman correlation analysis was performed to evaluate the correlation between T1 and APT values. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the differential performance of each parameter and their combination. The difference between AUCs was compared using the DeLong test.

Results: The APT value in patients with LN metastasis was significantly higher than in those without LN metastasis group (P=0.020). Also, similar results were observed for the T1 values (P=0.001). The area under the ROC curve of the APT value in the prediction of LN metastasis was 0.794; when the cutoff value was 1.73%, the sensitivity and specificity were 71.4% and 88.9%, respectively. The area under the ROC curve of the T1 value was 0.913; when the cutoff value was 1367.36 ms, the sensitivity and specificity were 78.6% and 100.0%, respectively. The area under the ROC curve of T1+APT was 0.929, with a sensitivity of 78.6% and specificity of 100.0%.

Conclusion: APT and T1 values show great diagnostic efficiency in predicting LN metastasis in rectal cancer.

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用于预测直肠癌患者淋巴结转移的 T1 图谱和酰胺质子转移加权成像技术

背景：术前准确判断淋巴结（LN）转移是制定治疗策略和评估直肠癌（RC）患者预后的关键一步：本研究旨在探讨T1图谱和酰胺质子转移加权（APTw）成像在预测直肠癌患者淋巴结转移方面的价值：在一项回顾性研究中，选取了23例病理确诊的直肠腺癌患者，这些患者在2019年8月至2021年8月期间接受了MRI检查和手术。然后，3.0T/MR 序列包括常规序列（T1WI、T2WI 和 DWI）、APTw 成像和 T1 映射。患者被分为LN转移组（A组）和非LN转移组（B组）。组内相关系数（ICC）用于检验观察者之间的一致性。Mann-Whitney U 检验用于比较两组之间的差异。斯皮尔曼相关分析用于评估 T1 和 APT 值之间的相关性。进行逻辑回归和接收器操作特征（ROC）曲线分析，以评估各参数及其组合的不同性能。使用 DeLong 检验比较 AUC 之间的差异：结果：LN转移患者的APT值明显高于无LN转移组（P=0.020）。此外，T1 值也有类似结果（P=0.001）。APT 值预测 LN 转移的 ROC 曲线下面积为 0.794；当临界值为 1.73% 时，敏感性和特异性分别为 71.4% 和 88.9%。T1 值的 ROC 曲线下面积为 0.913；当临界值为 1367.36 ms 时，敏感性和特异性分别为 78.6% 和 100.0%。T1+APT的ROC曲线下面积为0.929，敏感性为78.6%，特异性为100.0%：APT和T1值在预测直肠癌LN转移方面具有很高的诊断效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Imaging Reviews 医学-核医学

CiteScore

2.60

自引率

0.00%

发文量

246

审稿时长

1 months

期刊介绍： Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.