Age-Period-Cohort Analysis of Long-Term Trends in Ischemic Stroke Mortality in China Caused by Specific Risk Factors from 1990 to 2019.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Neuroepidemiology Pub Date : 2024-01-01 Epub Date: 2024-01-31 DOI:10.1159/000536014

Fude Liu, Peng Sun, Yawen Cheng, Jianyi Wang, Wenlong Ma, Chen Chen, Suhang Shang, Jia Yu

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Abstract

Objective: The objective of this study was to study the primary risk factors for the long-term trends of mortality rates in ischemic stroke (IS) in China.

Methods: Using the Global Burden of Disease Study 2019 (GBD 2019) database, research was conducted on the 11 primary risk factors for the mortality rates of IS in China from 1990 to 2019. This study employed joinpoint regression software and the age-period-cohort method to evaluate the trends of mortality rates divided by age, period, and cohort over time.

Results: From 1990 to 2019, the age-standardized mortality rate (ASMR) caused by a diet high in red meat and high body mass index in China showed an upward trend. ASMR increased first and then decreased due to smoking, diet high in sodium, particulate matter pollution, high fasting plasma glucose, and high systolic blood pressure. Low-density lipoprotein cholesterol (LDL-C), kidney dysfunction, low temperature, and lead exposure remained relatively stable during this period. In the 35-45 age group, the mortality rate of IS due to high LDL-C was up to about 60%, and smoking affected men more than women. Overall, high LDL-C, high systolic blood pressure, and particulate matter pollution were the most common risk factors in patients with IS. The risk of death rose with age. The period and cohort relative risks showed that metabolic risk factors had the greatest impact on the mortality of IS.

Conclusion: Metabolic risk factors have become the primary risk factors for the ASMR of IS in China. Relevant authorities should pay attention to their long-term effects on IS. Effective public health policies and interventions should be implemented to reduce the burden of IS.

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1990-2019年特定风险因素导致的中国缺血性脑卒中死亡率长期趋势的年龄-时期-队列分析。

目的：研究中国缺血性脑卒中（IS）死亡率长期趋势的主要危险因素：研究中国缺血性脑卒中（IS）死亡率长期趋势的主要危险因素：利用《全球疾病负担研究2019》（GBD 2019）数据库，对1990-2019年中国缺血性脑卒中死亡率的11个主要危险因素进行研究。本研究采用Joinpoint回归软件和年龄-时期-队列（APC）方法，评估死亡率按年龄、时期和队列划分的长期趋势：从 1990 年到 2019 年，中国因高红肉饮食和高体重指数（BMI）导致的年龄标准化死亡率（ASMR）呈上升趋势。吸烟、高钠饮食、颗粒物污染、高空腹血糖和高收缩压导致的年龄标准化死亡率先上升后下降。在此期间，低密度脂蛋白胆固醇（LDL-C）、肾功能障碍、低温和铅暴露保持相对稳定。在 35-45 岁年龄组中，高低密度脂蛋白胆固醇导致的 IS 死亡率高达约 60%，吸烟对男性的影响大于女性。总体而言，高低密度脂蛋白胆固醇、高收缩压和颗粒物污染是 IS 患者最常见的风险因素。死亡风险随着年龄的增长而上升。期间和队列相对风险显示，代谢风险因素对IS死亡率的影响最大：结论：代谢性危险因素已成为中国IS ASMR的主要危险因素。结论：代谢性危险因素已成为中国 IS ASMR 的主要危险因素，相关部门应关注其对 IS 的长期影响。应实施有效的公共卫生政策和干预措施，以减轻IS的负担。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.