Sex and Socioeconomic Disparities in Dementia Risk: A Population-Attributable Fraction Analysis in Argentina.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Neuroepidemiology Pub Date : 2024-01-01 Epub Date: 2024-01-31 DOI:10.1159/000536524

Ismael Luis Calandri, Gill Livingston, Regina Paradela, Rik Ossenkoppele, Lucia Crivelli, Ricardo F Allegri, Claudia K Suemoto

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Abstract

Introduction: Twelve modifiable risk factors (RFs) account for 40% of dementia cases worldwide. However, limited data exist on such factors in middle- and low-income countries. We aimed to estimate the population-attributable fractions (PAFs) for the 12 RFs in Argentina, assessing changes over a decade and exploring socioeconomic and sex influences.

Methods: We conducted cross-sectional analyses of the 12 RFs from Argentinian surveys conducted in 2009, 2015, and 2018, including 96,321 people. We calculated PAFs and stratified estimates based on sex and income.

Results: We estimated an overall PAF of 59.6% (95% CI = 58.9-60.3%). The largest PAFs were hypertension = 9.3% (8.7-9.9%), physical inactivity = 7.4% (6.8-8.2%), and obesity = 7.4% (6.8-7.9%). Men were more impacted by excessive alcohol, while women by isolation and smoking. Lower income linked to higher PAFs in education, hypertension, and obesity.

Discussion: Argentina has a higher PAF for dementia than the world population, with distinct RF distribution. PAF varied by sex and economic status, advocating tailored prevention strategies.

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痴呆症风险中的性别和社会经济差异：阿根廷人口可归因分数分析。

引言：全世界 40% 的痴呆症病例是由十二个可改变的风险因素（RF）造成的。然而，中低收入国家有关这些因素的数据却很有限。我们的目的是估算阿根廷 12 个可改变风险因素的人口可归因分数 (PAF)，评估十年间的变化，并探讨社会经济和性别的影响因素。方法：我们对阿根廷在 2009 年、2015 年和 2018 年进行的调查中得出的 12 项 RF 进行了横断面分析，调查对象包括 96,321 人。我们计算了 PAF，并根据性别和收入对估计值进行了分层。结果，我们估计总体 PAF 为 59.6%（95%CI=58.9%-60.3%）。最大的 PAF 为高血压=9.3%（8.7%-9.9%）、缺乏运动=7.4%（6.8%-8.2%）和肥胖=7.4%（6.8%-7.9%）。男性受过度饮酒的影响更大，而女性则受孤独和吸烟的影响更大。收入越低，教育、高血压和肥胖的 PAFs 越高。讨论：阿根廷的痴呆症PAF高于全球人口，且有明显的RF分布。PAF因性别和经济状况而异，因此应采取有针对性的预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.