Fluoride in drinking groundwater and prevalence of fluorosis in children and adolescents: A systematic review.

Francineudo Oliveira Chagas, Lidia A Rocha Valadas, Ana Sorazabal, Adeyinka Dayo, Thereza CF Botelho Dantas, Aldo Squassi
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Abstract

Fluorosis is a worldwide public health problem. One of the factors related to it is the type of water consumed, such as groundwater. High fluoride concentration in groundwater may be explained by contamination from local industries. Since fluoride and arsenic are the main pollutants of groundwater, some studies correlate groundwater consumption with high prevalence of fluorosis.

Aim: The aim of this study was to conduct a systematic review to determine whether children's risk of fluorosis is related to drinking groundwater.

Materials and method: The protocol for this systematic review was registered at the National Institute of Health Research Database (CRD42021227298). A comprehensive search was conducted to identify potentially relevant studies by exploring a range of electronic databases (Medline via PubMed, Scopus, Cochrane Library, Science Direct, Web of Science Core Collection, Medline via Ovid, Lilacs, Embase, and grey literature).

Results: A total 2189 articles were found. After reading titles and abstracts, 63 were selected for screening, and the final data was extracted from 15 articles.

Conclusion: A relationship was identified between drinking fluoridated water from wells and the prevalence of fluorosis in individuals up to 18 years old. This is the first study to assess the issue systematically worldwide.

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饮用地下水中的氟与儿童和青少年氟中毒的发病率:系统综述。
氟中毒是一个世界性的公共健康问题。与此相关的因素之一是饮用水的类型,如地下水。地下水中氟化物浓度高的原因可能是当地工业造成的污染。由于氟和砷是地下水的主要污染物,一些研究将饮用地下水与氟中毒的高发病率联系起来。目的:本研究旨在进行系统性综述,以确定儿童患氟中毒的风险是否与饮用地下水有关:本系统综述的方案已在美国国家健康研究所研究数据库(CRD42021227298)注册。为了确定潜在的相关研究,我们对一系列电子数据库(Medline via PubMed、Scopus、Cochrane Library、Science Direct、Web of Science Core Collection、Medline via Ovid、Lilacs、Embase 和灰色文献)进行了全面检索:结果:共找到 2189 篇文章。在阅读了标题和摘要后,筛选出 63 篇文章,并从 15 篇文章中提取了最终数据:结论:研究发现,饮用含氟井水与 18 岁以下儿童氟中毒发病率之间存在关系。这是首次在全球范围内对这一问题进行系统评估的研究。
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