Quercetin nanocrystals prepared using a microfluidic chip with improved in vitro dissolution.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY Pharmaceutical Development and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-22 DOI:10.1080/10837450.2024.2315444

Guangyan Zheng, Wenli Wu, Zemei Liu, Yuanju Lv, Yongming Luo, Xin Che, Lihong Wang

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Abstract

Objective: In order to improve the dissolution property of quercetin (QCT), the quercetin nanocrystals (QNCs) were prepared in this study.

Methods: QNCs were prepared by a 100 μm diameter Y-shape microfluidic channel. Some impact factors affecting the generation of QNCs such as concentration and flow rate were investigated. Furthermore, the fluid mixing in the microfluidic channel was simulated by fluid software.

Results: XRPD and DSC analyses indicated that the prepared QNCs were amorphous. Stable QNCs with a particle size of 77.9 ± 3.63 nm and polydispersity index of 0.26 ± 0.02 were obtained. TEM showed that the as-prepared QNCs had a uniform spherical shape with an average particle size of about 100-300 nm. In the dissolution medium without cosolvent Tween -80, the dissolution of QCT was poor, its final accumulated dissolution was only 3.95%, while that of QNCs was 66%.

Conclusion: When QCT was changed to QNCs by microfluidic technology, its dissolution property could be obviously improved. Therefore, microfluidic technology as a new method to prepare nanocrystals has a good applying prospect in improving dissolution property for poorly water-soluble drugs.

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利用微流控芯片制备槲皮素纳米晶体，提高体外溶解度。

目的为了改善槲皮素（QCT）的溶解性能，本研究制备了槲皮素纳米晶体（QNCs）：方法：采用直径为100微米的Y形微流体通道制备QNCs。研究了影响 QNC 生成的一些影响因素，如浓度和流速。此外，还利用流体软件模拟了微流体通道中的流体混合情况：结果：XRPD 和 DSC 分析表明制备的 QNC 是无定形的。得到的稳定 QNC 粒径为 77.9 ± 3.63nm，多分散指数为 0.26 ± 0.02。TEM 显示，制备的 QNC 具有均匀的球形，平均粒径约为 100-300 nm。在不含助溶剂 Tween -80 的溶解介质中，QCT 的溶解度较差，其最终累积溶解度仅为 3.95%，而 QNCs 的溶解度为 66%：结论：利用微流体技术将 QCT 转化为 QNCs 后，其溶解性能明显改善。因此，微流控技术作为制备纳米晶体的一种新方法，在改善水溶性差药物的溶出性能方面具有良好的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Development and Technology 医学-药学

CiteScore

5.90

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Pharmaceutical Development & Technology publishes research on the design, development, manufacture, and evaluation of conventional and novel drug delivery systems, emphasizing practical solutions and applications to theoretical and research-based problems. The journal aims to publish significant, innovative and original research to advance the frontiers of pharmaceutical development and technology. Through original articles, reviews (where prior discussion with the EIC is encouraged), short reports, book reviews and technical notes, Pharmaceutical Development & Technology covers aspects such as: -Preformulation and pharmaceutical formulation studies -Pharmaceutical materials selection and characterization -Pharmaceutical process development, engineering, scale-up and industrialisation, and process validation -QbD in the form a risk assessment and DoE driven approaches -Design of dosage forms and drug delivery systems -Emerging pharmaceutical formulation and drug delivery technologies with a focus on personalised therapies -Drug delivery systems research and quality improvement -Pharmaceutical regulatory affairs This journal will not consider for publication manuscripts focusing purely on clinical evaluations, botanicals, or animal models.