Intravenous iron in patients with iron deficiency and heart failure: a review of modern evidence.

IF 2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Current Opinion in Cardiology Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI:10.1097/HCO.0000000000001121
Stormi E Gale, Andrew Willeford, Katherine Sandquist, Kristin Watson
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Abstract

Purpose of review: Iron deficiency is common in patients with heart failure, affecting up to half of ambulatory patients and an even greater percentage of patients admitted for acute decompensation. Iron deficiency in this population is also associated with poor outcomes, including worse quality of life in addition to increased hospitalizations for heart failure and mortality. Evidence suggests that patients with iron deficiency in heart failure may benefit from repletion with IV iron.

Recent findings: In this review, we outline the etiology and pathophysiology of iron deficiency in heart failure as well as various iron formulations available. We discuss evidence for intravenous iron repletion with a particular focus on recent studies that have evaluated its effects on hospitalizations and mortality. Finally, we discuss areas of uncertainty and future study and provide practical guidance for iron repletion.

Summary: In summary, there is overwhelming evidence that intravenous iron repletion in patients with iron deficiency in heart failure is both beneficial and safe. However, further evidence is needed to better identify which patients would most benefit from iron repletion as well as the ideal repletion strategy.

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缺铁性心力衰竭患者静脉注射铁剂:现代证据综述。
审查目的:铁缺乏症在心力衰竭患者中很常见,多达一半的非卧床患者和更高比例的因急性失代偿而入院的患者会受到影响。该人群缺铁还与不良预后有关,包括生活质量下降、心衰住院率和死亡率上升。有证据表明,心力衰竭缺铁患者可从静脉补铁中获益:在这篇综述中,我们概述了心力衰竭缺铁的病因和病理生理学,以及现有的各种铁制剂。我们讨论了静脉补铁的证据,特别关注了近期评估其对住院率和死亡率影响的研究。最后,我们讨论了存在不确定性的领域和未来的研究,并为铁剂补给提供了实用指导。总结:总之,有大量证据表明,对心力衰竭缺铁患者静脉补铁既有益又安全。然而,还需要进一步的证据来更好地确定哪些患者最受益于补铁以及理想的补铁策略。
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来源期刊
Current Opinion in Cardiology
Current Opinion in Cardiology 医学-心血管系统
CiteScore
4.20
自引率
4.30%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Cardiology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With fourteen disciplines published across the year – including arrhythmias, molecular genetics, HDL cholesterol and clinical trials – every issue also contains annotated reference detailing the merits of the most important papers.
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