Efficacy and Mechanisms of Natural Products as Therapeutic Interventions for Chronic Respiratory Diseases.

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-02-14 DOI:10.1142/S0192415X24500034
Fanli Jin, Pengbei Fan, Yuanyuan Wu, Qingzhen Yang, Jiansheng Li, Han Liu
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Abstract

Chronic respiratory diseases are long-term conditions affecting the airways and other lung components that are characterized by a high prevalence, disability rate, and mortality rate. Further optimization of their treatment is required. Natural products, primarily extracted from organisms, possess specific molecular and structural formulas as well as distinct chemical and physical properties. These characteristics grant them the advantages of safety, gentleness, accessibility, and minimal side effects. The numerous advances in the use of natural products for treating chronic respiratory diseases have provided a steady source of motivation for new drug research and development. In this paper, we introduced the pathogenesis of chronic respiratory diseases and natural products. Furthermore, we classified natural products according to their mechanism for treating chronic respiratory diseases and describe the ways in which these products can alleviate the pathological symptoms. Simultaneously, we elaborate on the signal transduction pathways and biological impacts of natural products' targeting. Additionally, we present future prospects for natural products, considering their combination treatment approaches and administration methods. The significance of this review extends to both the research on preventing and treating chronic respiratory diseases, as well as the advancement of novel drug development in this field.

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天然产品作为慢性呼吸道疾病治疗干预措施的功效和机制。
慢性呼吸系统疾病是一种影响气道和其他肺部成分的长期疾病,具有发病率高、致残率高和死亡率高的特点。需要进一步优化其治疗方法。天然产品主要从生物体中提取,具有特定的分子和结构式,以及独特的化学和物理特性。这些特性使其具有安全、温和、易得、副作用小等优点。天然产物在治疗慢性呼吸系统疾病方面取得的诸多进展为新药研发提供了源源不断的动力。本文介绍了慢性呼吸系统疾病的发病机理和天然产物。此外,我们还根据天然产物治疗慢性呼吸系统疾病的机理对其进行了分类,并介绍了这些天然产物缓解病理症状的方法。同时,我们还阐述了天然产物靶向的信号转导途径和生物学影响。此外,考虑到天然产品的综合治疗方法和给药方式,我们还介绍了天然产品的未来前景。本综述对预防和治疗慢性呼吸系统疾病的研究以及该领域新药开发的进展都具有重要意义。
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