Short-term blood pressure variability and brain functional network connectivity in older adults

Q4 Neuroscience Neuroimage. Reports Pub Date : 2024-02-14 DOI:10.1016/j.ynirp.2024.100198
Isabel J. Sible , Jung Yun Jang , Anna E. Blanken , John Paul M. Alitin , Allie Engstrom , Shubir Dutt , Anisa J. Marshall , Arunima Kapoor , Fatemah Shenasa , Aimée Gaubert , Amy Nguyen , Farrah Ferrer , David R. Bradford , Kathleen E. Rodgers , Mara Mather , S. Duke Han , Daniel A. Nation
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Abstract

Background

Blood pressure variability is increasingly linked with cerebrovascular disease and Alzheimer's disease, independent of mean blood pressure levels. Elevated blood pressure variability is also associated with attenuated cerebrovascular reactivity, which may have implications for functional hyperemia underpinning brain network connectivity. It remains unclear whether blood pressure variability is related to functional network connectivity. We examined relationships between beat-to-beat blood pressure variability and functional connectivity in brain networks vulnerable to aging and Alzheimer's disease.

Methods

53 community-dwelling older adults (mean [SD] age = 69.9 [7.5] years, 62.3% female) without history of dementia or clinical stroke underwent continuous blood pressure monitoring and resting state fMRI scan. Blood pressure variability was calculated as variability independent of mean. Functional connectivity was determined by resting state fMRI for several brain networks: default, salience, dorsal attention, fronto-parietal, and language. Multiple linear regression examined relationships between short-term blood pressure variability and functional network connectivity.

Results

Elevated short-term blood pressure variability was associated with lower functional connectivity in the default network (systolic: standardized ß = −0.30 [95% CI -0.59, −0.01], p = .04). There were no significant associations between blood pressure variability and connectivity in other functional networks or between mean blood pressure and functional connectivity in any network.

Discussion

Older adults with elevated short-term blood pressure variability exhibit lower resting state functional connectivity in the default network. Findings support the role of blood pressure variability in neurovascular dysfunction and Alzheimer's disease. Blood pressure variability may represent an understudied early vascular risk factor for neurovascular dysfunction relevant to Alzheimer's disease, with potential therapeutic implications.

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老年人短期血压变化与大脑功能网络连接
背景血压变异性与脑血管疾病和阿尔茨海默病的关系日益密切,与平均血压水平无关。血压变异性升高还与脑血管反应性减弱有关,这可能会对支撑大脑网络连接的功能性充血产生影响。目前还不清楚血压变异性是否与功能性网络连接有关。我们研究了易受衰老和阿尔茨海默病影响的大脑网络中逐次跳动的血压变异性与功能连通性之间的关系。方法53名居住在社区的老年人(平均 [SD] 年龄 = 69.9 [7.5] 岁,62.3% 为女性)接受了连续血压监测和静息状态 fMRI 扫描,他们没有痴呆或临床中风病史。血压变异性按独立于平均值的变异性计算。通过静息状态 fMRI 确定了几个大脑网络的功能连接性:默认网络、显著性网络、背侧注意网络、前顶叶网络和语言网络。多元线性回归检验了短期血压变异性与功能网络连通性之间的关系。结果短期血压变异性升高与默认网络功能连通性降低有关(收缩压:标准化 ß = -0.30 [95% CI -0.59, -0.01],p = .04)。讨论短期血压变异性升高的老年人在默认网络中表现出较低的静息状态功能连通性。研究结果支持血压变异性在神经血管功能障碍和阿尔茨海默病中的作用。血压变异性可能是与阿尔茨海默病相关的神经血管功能障碍的早期血管风险因素,但未被充分研究,具有潜在的治疗意义。
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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
自引率
0.00%
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0
审稿时长
87 days
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