Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

IF 2.8 4区 化学 Q2 CHEMISTRY, ANALYTICAL Chirality Pub Date : 2024-02-14 DOI:10.1002/chir.23647
Vinod Kumar Vashistha, Tarun Kumar, Suman Yadav, Dipak Kumar Das
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Abstract

Ibuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti-inflammatory drug (NSAID) comprising two enantiomers, (R)-IBP and (S)-IBP, collectively known as (RS)-IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state-of-the-art methods, including chromatographic techniques including high-performance liquid chromatography, gas chromatography, liquid chromatography–tandem mass spectrometry, and some other techniques. This review addresses pharmacokinetics, pharmacology, and side effects of each enantiomer, ensuring safe drug usage. By consolidating diverse analytical methods and their applicability in different matrices, this review serves as a valuable resource for researchers, analysts, and practitioners in pharmaceutical analysis, pharmacology, and clinical studies.

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对映体选择性分离和测定布洛芬:立体选择性药代动力学、药效学和分析方法。
布洛芬(IBP)是一种广泛使用的非甾体抗炎药(NSAID),2019 年美国处方量排名第 29 位,由两种对映体组成,即 (R)-IBP 和 (S)-IBP,统称为 (RS)-IBP。这篇重要综述探讨了对映体选择性分离和测定 IBP 对映体的分析技术,这对制药和临床应用至关重要。综述侧重于最先进的方法,包括高效液相色谱法、气相色谱法、液相色谱-串联质谱法等色谱技术以及其他一些技术。本综述探讨了每种对映体的药代动力学、药理学和副作用,以确保安全用药。通过整合各种分析方法及其在不同基质中的适用性,本综述为药物分析、药理学和临床研究领域的研究人员、分析师和从业人员提供了宝贵的资源。
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来源期刊
Chirality
Chirality 医学-分析化学
CiteScore
4.40
自引率
5.00%
发文量
124
审稿时长
1 months
期刊介绍: The main aim of the journal is to publish original contributions of scientific work on the role of chirality in chemistry and biochemistry in respect to biological, chemical, materials, pharmacological, spectroscopic and physical properties. Papers on the chemistry (physiochemical, preparative synthetic, and analytical), physics, pharmacology, clinical pharmacology, toxicology, and other biological aspects of chiral molecules will be published.
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