Salivary metabolites as potential predictive biomarkers for lung surgery complications: a retrospective cross-sectional study.

IF 1.6 4区医学 Q2 SURGERY Surgery Today Pub Date : 2024-08-01 Epub Date: 2024-02-15 DOI:10.1007/s00595-024-02794-1

Satoshi Takamori, Shigeo Ishikawa, Kaito Sato, Hikaru Watanabe, Jun Suzuki, Hiroyuki Oizumi, Satoshi Shiono, Tetsuro Uchida, Naoki Okuyama, Kaoru Edamatsu, Mitsuyoshi Iino, Masahiro Sugimoto

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Abstract

Purpose: Saliva is often used as a tool for identifying systemic diseases because of the noninvasive nature of its collection. Moreover, salivary metabolites can be potential predictive factors for postoperative survival. We conducted the present study to establish whether salivary metabolites can function as predictive biomarkers for lung surgery complications.

Methods: Unstimulated salivary samples were collected from 412 patients before lung surgery. Salivary metabolites were analyzed comprehensively by capillary electrophoresis mass spectrometry. Clinical data with the discriminatory ability of biomarkers were assessed to predict lung surgery complications using multivariate logistic regression analysis. The primary endpoint was the risk factors for postoperative complications of Clavien-Dindo grade ≥ III.

Results: Postoperative complications of Clavien-Dindo grade ≥ III developed in 36 patients (8.7%). There was no postoperative 30-day mortality. Male sex (odds ratio [OR], 3.852; 95% confidence interval CI 1.455-10.199; p = 0.007) and salivary gamma-butyrobetaine (OR, 0.809; 95% CI 0.694-0.943; p = 0.007) were identified as significant risk factors for postoperative complications of Clavien-Dindo grade ≥ III.

Conclusion: Salivary metabolites are potential noninvasive biomarkers for predicting postoperative complications of lung surgery.

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作为肺部手术并发症潜在预测生物标志物的唾液代谢物：一项回顾性横断面研究。

目的：由于唾液采集的无创性，唾液经常被用作识别全身性疾病的工具。此外，唾液代谢物还是术后存活率的潜在预测因素。本研究旨在确定唾液代谢物是否可作为肺部手术并发症的预测性生物标志物：方法：我们收集了 412 名肺部手术前患者的未受刺激唾液样本。采用毛细管电泳质谱法对唾液代谢物进行了全面分析。利用多变量逻辑回归分析评估了临床数据与生物标志物的鉴别能力，以预测肺部手术并发症。主要终点是Clavien-Dindo≥III级术后并发症的风险因素：结果：36 例患者（8.7%）术后出现 Clavien-Dindo ≥ III 级并发症。术后 30 天无死亡病例。男性（几率比 [OR]，3.852；95% 置信区间 CI 1.455-10.199；P = 0.007）和唾液中的γ-丁卡因（OR，0.809；95% 置信区间 CI 0.694-0.943；P = 0.007）被确定为克拉维恩-丁度≥ III 级术后并发症的重要风险因素：唾液代谢物是预测肺部手术术后并发症的潜在无创生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.