A Study of Sonodynamic Therapy of Melanoma C540 Cells in Vitro by Titania/Gold Nanoparticles.

Q3 Medicine Journal of Biomedical Physics and Engineering Pub Date : 2024-02-01 DOI:10.31661/jbpe.v0i0.2310-1674

Ghazale Perota, Parsa Faghani-Eskandarkolaei, Niloofar Zahraie, Mohammad Hosein Zare, Naghmeh Sattarahmady

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Abstract

Background: Sonodynamic Therapy (SDT), a safe and non-invasive strategy in tumor therapy, is in development using novel sono-sensitizers, activated by low-intensity ultrasound radiation. SDT mainly progresses through Reactive Oxygen Species (ROS) generation followed by cell annihilation.

Objective: The current study aimed to investigate the effect of ultrasound therapy with titania/gold nanoparticles (NPs) on melanoma cancer.

Material and methods: In this experimental study, Titania/gold NPs (TGNPs) were synthesized, and their activity was investigated in sonodynamic therapy of a melanoma cancer cell line (C540). SDT was performed at 1.0 W cm^-2 and 1.0 MHz for one minute.

Results: The synthesized NPs that comprised gold NPs of <10 nm into titania NPs of <20 nm showed great stability and cytocompatibility. While TGNPs were biocompatible, a remarkable rate of cell ablation was observed upon ultrasound irradiation due to ROS generation.

Conclusion: The SDT using TGNPs can be introduced as an alternative and low-cost treatment method for melanoma malignancy.

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利用钛/金纳米粒子对黑色素瘤 C540 细胞进行体外声动力治疗的研究

背景：声动力疗法（SDT）是一种安全、非侵入性的肿瘤治疗策略，目前正在开发使用新型声敏剂，由低强度超声辐射激活。SDT主要通过产生活性氧（ROS），然后消灭细胞：本研究旨在探讨二氧化钛/金纳米粒子（NPs）超声疗法对黑色素瘤的影响：在本实验研究中，合成了二氧化钛/金纳米粒子（TGNPs），并研究了其在黑色素瘤癌细胞系（C540）超声动力疗法中的活性。SDT在1.0 W cm-2和1.0 MHz的频率下进行，持续一分钟：合成的 NPs 由金 NPs 组成：使用 TGNPs 的 SDT 可作为黑色素瘤恶性肿瘤的一种低成本替代治疗方法。

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来源期刊

Journal of Biomedical Physics and Engineering Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Biomedical Physics and Engineering (JBPE) is a bimonthly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research (experimental or theoretical) broadly concerned with the relationship of physics to medicine and engineering.