Cerebellar cognitive affective syndrome with long-term features of autism spectrum disorder: evidence in a 9-year-old girl after vermian medulloblastoma surgery.

IF 1.6 3区 心理学 Q3 CLINICAL NEUROLOGY Child Neuropsychology Pub Date : 2024-10-01 Epub Date: 2024-02-16 DOI:10.1080/09297049.2024.2302691
Matilde Taddei, Sara Bulgheroni, Alessandra Erbetta, Flavia Faccio, Cesare Giorgi, Daria Riva
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Abstract

The time course of socio-communicative disturbances in children after posterior fossa tumor resection is variable in clinical reports, and its assessment may help to understand the role of the cerebellum in the pathogenesis of socio-communicative disorders and improve rehabilitation plans. We report the 3-year cognitive-behavioral follow-up of a female patient (LZ) who underwent surgical ablation of the vermis due to medulloblastoma at age 9. LZ developed a severe post-operative Cerebellar Cognitive Affective Syndrome (CCAS) with cognitive-executive dysfunctions and behavioral alterations resembling an Autism Spectrum Disorder (ASD)-like syndrome. The lack of empathy and reduced ability to recognize others' intentions and mental states persisted at follow-up evaluations, as did language alterations. The present case report evidenced that lesions affecting cerebellar and vermal lobules may cause severe CCAS and impairment of social skills overlapping with that observed in ASD. This case is significant in its clinical features, revealing long-term social impairment, while the cognitive, linguistic, and executive functioning improved over time. Prospective case studies should plan the evaluation of symptoms of ASD within the clinical longitudinal assessment.

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具有自闭症谱系障碍长期特征的小脑认知情感综合征:一名 9 岁女孩蚓部髓母细胞瘤手术后的证据。
在临床报告中,后窝肿瘤切除术后儿童社会交流障碍的时间过程不尽相同,对其进行评估有助于了解小脑在社会交流障碍发病机制中的作用并改进康复计划。我们报告了一名女性患者(LZ)3 年的认知行为随访,她在 9 岁时因髓母细胞瘤接受了蚓部手术消融。LZ 术后出现了严重的小脑认知情感综合征(CCAS),认知执行功能障碍和行为改变类似于自闭症谱系障碍(ASD)综合征。在随访评估中,患者仍然缺乏同理心,识别他人意图和精神状态的能力下降,语言也有改变。本病例报告证明,影响小脑和蚓部小叶的病变可能会导致严重的CCAS和社交能力损害,这与在ASD中观察到的情况相重叠。本病例的临床特征具有重要意义,它显示了长期的社交障碍,而认知、语言和执行功能随着时间的推移有所改善。前瞻性病例研究应计划在临床纵向评估中对 ASD 症状进行评估。
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来源期刊
Child Neuropsychology
Child Neuropsychology 医学-临床神经学
CiteScore
4.10
自引率
9.10%
发文量
71
审稿时长
>12 weeks
期刊介绍: The purposes of Child Neuropsychology are to: publish research on the neuropsychological effects of disorders which affect brain functioning in children and adolescents, publish research on the neuropsychological dimensions of development in childhood and adolescence and promote the integration of theory, method and research findings in child/developmental neuropsychology. The primary emphasis of Child Neuropsychology is to publish original empirical research. Theoretical and methodological papers and theoretically relevant case studies are welcome. Critical reviews of topics pertinent to child/developmental neuropsychology are encouraged. Emphases of interest include the following: information processing mechanisms; the impact of injury or disease on neuropsychological functioning; behavioral cognitive and pharmacological approaches to treatment/intervention; psychosocial correlates of neuropsychological dysfunction; definitive normative, reliability, and validity studies of psychometric and other procedures used in the neuropsychological assessment of children and adolescents. Articles on both normal and dysfunctional development that are relevant to the aforementioned dimensions are welcome. Multiple approaches (e.g., basic, applied, clinical) and multiple methodologies (e.g., cross-sectional, longitudinal, experimental, multivariate, correlational) are appropriate. Books, media, and software reviews will be published.
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