Phenocopy behavioral variant frontotemporal dementia: A case study.

IF 3 3区 心理学 Q2 CLINICAL NEUROLOGY Clinical Neuropsychologist Pub Date : 2024-07-01 Epub Date: 2024-02-15 DOI:10.1080/13854046.2024.2315726
Rachel M Peters, Christine M Schieszler-Ockrassa, Angela Gleason, Kathleen Patterson
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Abstract

Objective: Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative condition characterized by progressive changes in behavior, cognition, and day-to-day functioning. Progression of the disease usually leads to death 3-5 years after diagnosis. However, there are reports of individuals who are initially diagnosed with bvFTD but fail to progress. These individuals are thought to have what is becoming known as phenocopy bvFTD (phFTD). Methods: This manuscript reviews a single case study of a 68-year-old male Veteran who was diagnosed with bvFTD in 2010, which has not progressed over time. Results: Review of serial neuropsychological evaluations was broadly normal with mild evidence of executive dysfunction with minimal reliable change in his performances from 2015, 2017, and 2022 evaluations. He also has not developed neuroimaging evidence of FTD. Conclusions: This case illustrates the importance of monitoring individuals over time and incorporating neuroimaging data into the diagnosis. We believe this Veteran's presentation is most consistent with what has been described as phFTD.

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表型行为变异性额颞叶痴呆症:病例研究。
目的:行为变异性额颞叶痴呆症(bvFTD)是一种神经退行性疾病,以行为、认知和日常功能的渐进性改变为特征。病情恶化通常会导致患者在确诊后 3-5 年死亡。不过,也有报告称,有些人最初被诊断为 bvFTD,但病情没有进展。这些人被认为患有所谓的表型 bvFTD(phFTD)。方法:本手稿回顾了一例研究,研究对象是一名 68 岁的男性退伍军人,他于 2010 年被诊断为 bvFTD,但随着时间的推移,病情并未发展。研究结果连续的神经心理学评估结果大致正常,有轻微的执行功能障碍证据,2015 年、2017 年和 2022 年的评估结果对其表现的可靠改变极小。他也没有出现 FTD 的神经影像学证据。结论:本病例说明了对患者进行长期监测并将神经影像学数据纳入诊断的重要性。我们认为这名退伍军人的表现最符合 phFTD 的描述。
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来源期刊
Clinical Neuropsychologist
Clinical Neuropsychologist 医学-临床神经学
CiteScore
8.40
自引率
12.80%
发文量
61
审稿时长
6-12 weeks
期刊介绍: The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.
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