Transmission of drug-resistant Mycobacterium tuberculosis isolates between Finnish- and foreign-born cases, 2014–2021: A molecular epidemiological study

IF 2.8 3区医学 Q3 IMMUNOLOGY Tuberculosis Pub Date : 2024-02-12 DOI:10.1016/j.tube.2024.102492

Jiahui Zhu , Marjo Haanpera , Silja Mentula , Olli Vapalahti , Hanna Soini , Tarja Sironen , Ravi Kant , Fathiah Zakham

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Abstract

Background

Data on the molecular epidemiology and transmission of drug-resistant Mycobacterium tuberculosis (MTB) in low-incidence settings with immigration from high-incidence settings is limited.

Method

We included 115 drug-resistant (DR) MTB isolates with whole-genome sequencing data isolated in Finland between 2014 and 2021. Potential transmission clusters were identified using a threshold of 12 single-nucleotide polymorphisms (SNPs). Highly related clusters were identified using a threshold of 5 SNPs.

Result

Of the 115 DR MTB isolates, 31 (27.0%) isolates were from Finnish-born cases and 84 (73.0%) were from foreign-born cases. The proportion of multidrug-resistant (MDR) MTB isolates (30/84, 35.7%) from foreign-born cases was higher than that of MDR MTB isolates from Finnish-born cases (8/31, 25.8%). Lineage 2 (40/115, 34.8%) and lineage 4 (40/115, 34.8%) were the most prevalent lineages. A total of 25 (21.7%) isolates were classified into eight potential transmission clusters (≤12 SNPs). Furthermore, five highly related clusters (≤5 SNPs) were identified, including three DR MTB isolates from Finnish-born cases and 14 DR isolates from foreign-born cases.

Conclusion

The risk of DR MTB transmission between Finnish- and foreign-born persons is not negligible. Further research on clustering analysis in drug-susceptible MTB is worth to inform tuberculosis management and control in low-incidence settings with increasing immigration.

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2014-2021年芬兰和外国出生病例之间耐药结核分枝杆菌分离株的传播：分子流行病学研究

背景有关耐药结核分枝杆菌（MTB）的分子流行病学和在低发病率地区的传播以及从高发病率地区移民的数据十分有限。方法我们纳入了 2014 年至 2021 年期间在芬兰分离的 115 例具有全基因组测序数据的耐药（DR）MTB 分离物。以 12 个单核苷酸多态性（SNPs）为阈值，确定潜在的传播集群。在115个DR MTB分离株中，31个（27.0%）来自芬兰出生的病例，84个（73.0%）来自外国出生的病例。来自外国出生病例的耐多药（MDR）MTB分离株比例（30/84，35.7%）高于来自芬兰出生病例的耐多药MTB分离株比例（8/31，25.8%）。2系（40/115，34.8%）和4系（40/115，34.8%）是最常见的菌系。共有 25 个（21.7%）分离株被归入 8 个潜在传播集群（≤12 个 SNPs）。此外，还发现了五个高度相关的集群（≤5个SNPs），其中包括3个来自芬兰出生病例的DR MTB分离株和14个来自外国出生病例的DR分离株。在移民日益增多的低发病率地区，对药物敏感型 MTB 的聚类分析值得进一步研究，以便为结核病的管理和控制提供信息。

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来源期刊

Tuberculosis 医学-呼吸系统

CiteScore

4.60

自引率

3.10%

发文量

审稿时长

49 days

期刊介绍： Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The journal publishes original research and reviews on the host response and immunology of tuberculosis and the molecular biology, genetics and physiology of the organism, however discourages submissions with a meta-analytical focus (for example, articles based on searches of published articles in public electronic databases, especially where there is lack of evidence of the personal involvement of authors in the generation of such material). We do not publish Clinical Case-Studies. Areas on which submissions are welcomed include: -Clinical TrialsDiagnostics- Antimicrobial resistance- Immunology- Leprosy- Microbiology, including microbial physiology- Molecular epidemiology- Non-tuberculous Mycobacteria- Pathogenesis- Pathology- Vaccine development. This Journal does not accept case-reports. The resurgence of interest in tuberculosis has accelerated the pace of relevant research and Tuberculosis has grown with it, as the only journal dedicated to experimental biomedical research in tuberculosis.