{"title":"Sclareol: Isolation, Structural Modification, Biosynthesis, and Pharmacological Evaluation – A Review","authors":"Salman Jameel, Khursheed Ahmad Bhat","doi":"10.1007/s11094-024-03050-z","DOIUrl":null,"url":null,"abstract":"<p>Sclareol, isolated from a variety of plant species like <i>Salvia sclarea</i>, is a labdane diterpene of high value for the flavour and fragrance industries. Sclareol is biosynthetically produced through the methylerythritol-phosphate (MEP) pathway. It is a nontoxic molecule used as a topical and oral product. This bicyclic diterpene alcohol is a key starting natural product for the preparation of the high-value perfume ingredient ambroxide. A number of research studies regarding sclareol chemistry, biosynthesis and pharmacological activities are reported in the literature. The present review is an attempt to compile the different aspects of sclareol. The review presents the occurrence, biosynthesis, pharmacological properties and structural modifications of sclareol.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical Chemistry Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11094-024-03050-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Sclareol, isolated from a variety of plant species like Salvia sclarea, is a labdane diterpene of high value for the flavour and fragrance industries. Sclareol is biosynthetically produced through the methylerythritol-phosphate (MEP) pathway. It is a nontoxic molecule used as a topical and oral product. This bicyclic diterpene alcohol is a key starting natural product for the preparation of the high-value perfume ingredient ambroxide. A number of research studies regarding sclareol chemistry, biosynthesis and pharmacological activities are reported in the literature. The present review is an attempt to compile the different aspects of sclareol. The review presents the occurrence, biosynthesis, pharmacological properties and structural modifications of sclareol.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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