{"title":"Innovative and sustainable synthesis and structure of novel N‐substituted hexahydroacridine derivatives","authors":"Nangagoundan Vinoth, C. Kalaiarasi, A. Lalitha","doi":"10.1002/poc.4604","DOIUrl":null,"url":null,"abstract":"An efficient and green synthesis of tetramethyl‐10‐(phenylamino)‐3,4,6,7,9,10‐hexahydroacridine‐1,8(2H,5H)‐dione derivatives has been achieved from various substituted aryl aldehydes, 5,5‐dimethyl‐3‐(2‐phenylhydrazinyl)cyclohex‐2‐enone and dimedone in aqueous ethanol medium. Environment‐friendly reaction, excellent yields, operational simplicity and shorter reaction times are the significant features of the present protocol. All the synthesized compounds were characterized by various spectroscopic techniques and X‐ray crystal diffraction studies.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"25 19","pages":""},"PeriodicalIF":17.7000,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/poc.4604","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
An efficient and green synthesis of tetramethyl‐10‐(phenylamino)‐3,4,6,7,9,10‐hexahydroacridine‐1,8(2H,5H)‐dione derivatives has been achieved from various substituted aryl aldehydes, 5,5‐dimethyl‐3‐(2‐phenylhydrazinyl)cyclohex‐2‐enone and dimedone in aqueous ethanol medium. Environment‐friendly reaction, excellent yields, operational simplicity and shorter reaction times are the significant features of the present protocol. All the synthesized compounds were characterized by various spectroscopic techniques and X‐ray crystal diffraction studies.
在乙醇水溶液介质中，以各种取代的芳基醛、5,5-二甲基-3-(2-苯肼基)环己-2-烯酮和二咪酮为原料，高效、绿色地合成了四甲基-10-(苯基氨基)-3,4,6,7,9,10-六氢吖啶-1,8(2H,5H)-二酮衍生物。本方案的显著特点是反应对环境友好、产率高、操作简单和反应时间短。所有合成化合物都通过各种光谱技术和 X 射线晶体衍射研究进行了表征。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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