Evaluation of the effects of hempseed cake on plasma metabolites and cytokines in response to an LPS challenge in finishing steers

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-12 DOI:10.1139/cjas-2023-0085

Thomas M. Winders, S. Amat, Kendall Swanson

引用次数: 0

Abstract

A lipopolysaccharide (LPS; 0.25 µg LPS/kg of BW) challenge in steers (n = 5; initial BW = 542 kg, SD = 40 kg; Youden square) was conducted to evaluate feeding 0% (dry matter basis; control) or 20% hempseed cake (HEMP) or corn distillers grains (DDGS) on plasma metabolites and cytokines. Plasma isoleucine, leucine, tryptophan, aspartic acid, glycine, tyrosine, total nonessential amino acids, IL-1α, IL-36RA, and TNF-α decreased (P ≤ 0.04) in steers fed hempseed cake compared to steers fed DDGS after the LPS challenge. These data suggest that hempseed cake may influence inflammation by altering cytokine production and by increasing degradation and/or utilization of some amino acids.

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评估大麻籽饼对育成公牛面对 LPS 挑战时血浆代谢物和细胞因子的影响

我们对母牛（n = 5；初始体重 = 542 千克，SD = 40 千克；尤登方格）进行了脂多糖（LPS；0.25 µg LPS/千克体重）挑战，以评估饲喂 0%（干物质基础；对照组）或 20% 大麻籽饼（HEMP）或玉米蒸馏谷物（DDGS）对血浆代谢物和细胞因子的影响。与饲喂 DDGS 的母牛相比，饲喂麻籽饼的母牛在受到 LPS 挑战后血浆中的异亮氨酸、亮氨酸、色氨酸、天冬氨酸、甘氨酸、酪氨酸、非必需氨基酸总量、IL-1α、IL-36RA 和 TNF-α 均有所下降（P ≤ 0.04）。这些数据表明，大麻籽饼可能会通过改变细胞因子的产生和增加某些氨基酸的降解和/或利用来影响炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.