OPTIMAL CONTROL ON FRACTIONAL ENZYME KINETICS WITH INHIBITORS

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-01 DOI:10.1142/s0218339024500189
M. Vellappandi, J. Kokila, V. Govindaraj
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Abstract

In enzyme kinetic chemical reaction, inhibitors are working as a regulators of the metabolism of the systems and the biochemical activities as well. The main focus of this study is to explore the fractional dynamics of enzyme kinetic biochemical reactions with competitive and uncompetitive inhibitors. Further, the analysis continuous with the optimal controls on the system which accelerate biochemical reactions and maximize product generation. Eventually, the numerical analysis have been done by the Adams predictor–corrector method and the forward–backward sweep method for the dynamics and optimal control study, respectively.
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带抑制剂的部分酶动力学优化控制
在酶促化学反应中,抑制剂是系统代谢和生化活动的调节剂。本研究的重点是探索有竞争性和无竞争性抑制剂的酶促生化反应的分数动态。此外,分析还包括对系统的最佳控制,以加速生化反应并最大限度地生成产物。最后,在动力学和最优控制研究中,分别采用亚当斯预测-校正方法和前向-后向扫频方法进行了数值分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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