Vitamin D-Binding Protein and the Role of its Gene Polymorphisms in the Mortality of Sepsis Patients

Q3 Medicine Acta medica academica Pub Date : 2024-02-01 DOI:10.5644/ama2006-124.428
Liliriawati Ananta Kahar, Y. Yusrawati, Jamsari Jamsari, T. Maskoen, Kornelis Aribowo, Wiwi Monika Sari
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Abstract

Objective. This study aimed to determine the role of vitamin D-binding protein (VDBP) gene polymorphisms (especially at locus rs7041), vitamin D-binding protein levels, and vitamin D levels in mortality in sepsis patients. Patients and Methods. We performed the analytic observational study with a case-control approach. A total of 80 patients were included in this study, 40 patients were grouped as the case group and 40 patients were grouped as the control group. The patients were diagnosed with sepsis and treated in the Intensive Care Unit (ICU), M. Djamil Hospital, Indonesia. The VDBP rs7041 gene polymorphism was analyzed using the polymerase chain reaction procedure. VDBP and vitamin D levels were examined using the enzyme-linked immunosorbent assay (ELISA) method. Results. The case group showed lower mean vitamin D and VDBP levels than the con- trol group (P<0.05). There were more variations in the rs7041 gene VDBP (mutant) locus in the case group than in the control group, and this difference was considered statistically significant, P<0.05. The results of this study indicate that the occurrence of polymorphism or variations at locus rs7401 (mutant) causes a decrease in VDBP and vitamin D levels. A decrease in vitamin D levels correlates with the incidence of mortality in sepsis patients. Conclusion. Polymorphism gene VDBP at locus rs7041 causes a decrease in the production of VDBP, a vitamin D carrier protein.
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维生素 D 结合蛋白及其基因多态性在败血症患者死亡率中的作用
研究目的本研究旨在确定维生素 D 结合蛋白(VDBP)基因多态性(尤其是位点 rs7041)、维生素 D 结合蛋白水平和维生素 D 水平在败血症患者死亡率中的作用。患者和方法。我们采用病例对照方法进行了分析性观察研究。本研究共纳入 80 例患者,其中 40 例为病例组,40 例为对照组。这些患者被诊断为败血症,并在印度尼西亚 M. Djamil 医院重症监护室(ICU)接受治疗。采用聚合酶链反应程序分析了 VDBP rs7041 基因多态性。采用酶联免疫吸附试验(ELISA)方法检测VDBP和维生素D水平。结果显示病例组的维生素 D 和 VDBP 平均水平低于对照组(P<0.05)。病例组 VDBP(突变)基因 rs7041 位点的变异多于对照组,差异有统计学意义(P<0.05)。本研究结果表明,基因位点 rs7401(突变体)的多态性或变异会导致 VDBP 和维生素 D 水平下降。维生素 D 水平的降低与败血症患者的死亡率相关。结论基因 VDBP 位点 rs7041 的多态性会导致维生素 D 载体蛋白 VDBP 的生成减少。
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来源期刊
Acta medica academica
Acta medica academica Medicine-Medicine (all)
CiteScore
1.90
自引率
0.00%
发文量
21
审稿时长
15 weeks
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