Lamina Cribrosa Thickness in Patients with Branch Retinal Vein Occlusion: A Cross Sectional Comparative Evaluation Using Enhanced Depth Imaging Optical Coherence Tomography

Rahul Bhardwaj, Aeshvarya Dhawan, V. Vats, Priyanka Gupta, Anupam Singh, Nidhi Tomar
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Abstract

Retinal vein occlusion (RVO) is one of the most common causes of retinal vascular disease, second to diabetic retinopathy. We aimed to compare the lamina cribrosa thickness (LCT) of patients with unilateral branch RVO (BRVO) versus healthy individuals. This was a hospital-based, prospective, cross-sectional, and comparative study. Participants were newly diagnosed RVO cases (n = 25) and apparently normal age-matched healthy controls (n = 25). All the participants underwent systemic and comprehensive ophthalmic examination, including refraction and enhanced depth imaging optical coherence tomography. Relevant parameters were compared between the groups using the independent t-test. Statistical significance thresholds were set at a P < 0.05. The mean age of cases (66.7% female) and controls (52% female) was 55.9 ± 7.4 and 59.4 ± 7.0 years, respectively, (P = 0.089). The mean LCT of the affected eyes in cases (176.6 ± 28.3 μm) was significantly lower compared to the unaffected eyes of cases (200.6 ± 33.1 μm, P = 0.008) and control eye (230.9 ± 36.9 μm, P = 0.001). A thinner lamina cribrosa (LC) was observed in both eyes of unilateral RVO patients compared with healthy, nonglaucomatous subjects’ eyes. The role of LCT as a local mechanical factor in the pathogenesis of BRVO and their relationship to systemic factors merits further investigation.
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视网膜静脉分支闭塞患者的脉络膜厚度:使用增强深度成像光学相干断层扫描进行横截面比较评估
视网膜静脉阻塞(RVO)是导致视网膜血管疾病的最常见原因之一,仅次于糖尿病视网膜病变。我们的目的是比较单侧分支视网膜静脉阻塞(BRVO)患者与健康人的脉络膜厚度(LCT)。 这是一项基于医院的前瞻性横断面比较研究。研究对象为新确诊的 RVO 病例(25 人)和明显正常的年龄匹配健康对照组(25 人)。所有参与者都接受了系统和全面的眼科检查,包括屈光和增强深度成像光学相干断层扫描。组间相关参数的比较采用独立 t 检验。统计显著性阈值设定为 P <0.05。 病例(66.7% 为女性)和对照组(52% 为女性)的平均年龄分别为 55.9 ± 7.4 岁和 59.4 ± 7.0 岁(P = 0.089)。与未受影响的病例眼(200.6 ± 33.1 μm,P = 0.008)和对照眼(230.9 ± 36.9 μm,P = 0.001)相比,病例眼的平均 LCT(176.6 ± 28.3 μm)明显较低。 与健康的非白内障受试者的眼睛相比,单侧 RVO 患者的双眼中均观察到较薄的颅底薄层(LC)。LCT作为局部机械因素在BRVO发病机制中的作用及其与全身因素的关系值得进一步研究。
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