CARDIOPROTECTIVE EFFECT OF TRIKATU CHURNA ON ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION

Abstract

Objective: The goal of this study aimed to evaluate the protective and vascular effect of the polyherbal trikatu in rats on isoproterenol (ISO) triggered myocardial infarction (MI). Methods: For a total of two days in a row at 24 h breaks (27th and 28th d), a subcutaneous (s.c.) injection of isoproterenol (85 mg/kg body weight) was used to induce myocardial infarction. The rats in Group I behaved as the normal control without pretreatment. Rats in Group II were given isoproterenol. The rats in Group III were selected as the standard, treated with vitamin E (10 mg/kg, p.o.) for 28 d and subjected to isoproterenol (ISO) toxicity. Rats of Group IV and Group V received test sample trikatu 100 mg/kg and 200 mg/kg, respectively for 28 d and were subjected to isoproterenol (ISO) toxicity. Results: Rats given isoproterenol treatment revealed a considerable elevation of serum enzyme cardiac troponin I (cTnI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), Heart creatinine kinase (CK-MB), Lactase dehydrogenase (LDH). Rats pretreated with trikatu and vitamin E+ISO showed significant different (p<0.001) for AST, ALT, LDH and CK-MB levels elevated by ISO. Histopathological tests showed that trikatu and vitamin E decreased inflammation and edema in the hearts of rats. Conclusion: The aqueous suspension of trikatu churna was found to be significantly helpful in minimizing the magnitude of myocardial damage and combating oxidative stress.