Molecular and Genetic Profile in Salivary Gland Tumours

Abstract

The classification of salivary gland tumours, according to the World Health Organization (WHO), is a system used to classify benign and malignant tumours of the salivary glands. It is based on the histopathological features of the tumours, such as the type of cells involved, the degree of differentiation and any malignant features. In addition to the WHO classification, other systems are used to classify salivary gland tumours. One such system is the Milan system, which is used to classify salivary gland tumours based on their cytological features. This article reviews the consistently occurring prolific genetic alterations and novel molecular changes that include TP53, NOTCH1, PIK3CA, CDKN2A and ERBB2, as seen in salivary gland tumours.